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cluvenone

an antineoplastic agent; structure in first source

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Xanthones: 211
        cluvenone: 4

Experts

1.	Theodorakis, Emmanuel A: 4 articles (03/2015 - 12/2009)
2.	Batova, Ayse: 3 articles (10/2012 - 12/2009)
3.	Yu, Alice L: 2 articles (10/2012 - 11/2010)
4.	Chantarasriwong, Oraphin: 2 articles (11/2010 - 12/2009)
5.	Bai, Fang: 1 article (03/2015)
6.	Darash-Yahana, Merav: 1 article (03/2015)
7.	Holt, Sarah H: 1 article (03/2015)
8.	Jennings, Patricia A: 1 article (03/2015)
9.	Lipper, Colin H: 1 article (03/2015)
10.	Luo, Yuting: 1 article (03/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2012 - "In conclusion, cluvenone, an agent with potent cytotoxicity against multi-drug resistant tumor cells, has direct targets in mitochondria thus setting precedence for drug discovery efforts against these targets in the treatment of refractory cancers." 11/01/2010 - "Importantly, cluvenone was approximately 5-fold more potent against a primary B-cell acute lymphoblastic leukemia compared with peripheral blood mononuclear cells from normal donors, suggesting that it has significant tumor selectivity. " 03/24/2015 - "Here, we report that MAD-28, a designed cluvenone (CLV) derivative, binds to and destabilizes two members of a unique class of mitochondrial and endoplasmic reticulum (ER) 2Fe-2S proteins, mitoNEET (mNT) and nutrient-deprivation autophagy factor-1 (NAF-1), recently implicated in cancer cell proliferation. " 10/01/2012 - "The synthetic caged Garcinia xanthone, cluvenone, has potent and selective cytotoxicity against numerous cancer cell lines including those that are multi-drug resistant. "
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/01/2010 - "Cluvenone was found to induce apoptosis in T-cell acute lymphoblastic leukemia cells (EC₅₀ = 0.25 μmol/L) and had potent growth-inhibitory activity against the NCI60 cell panel, including those that are multidrug-resistant, with a GI₅₀ range of 0.1 to 2.7 μmol/L. " 11/01/2010 - "Importantly, cluvenone was approximately 5-fold more potent against a primary B-cell acute lymphoblastic leukemia compared with peripheral blood mononuclear cells from normal donors, suggesting that it has significant tumor selectivity. "
3.	Leukemia 12/07/2009 - "Studies with cluvenone (7) also showed that these compounds induce apoptosis and exhibit significant cytotoxicity in multidrug-resistant leukemia cells. " 10/01/2012 - "Examination of Cyt c levels in leukemia cells treated with 1 μM cluvenone resulted in a 4-fold increase in levels of both cytosolic and mitochondrial Cyt c. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	xanthone