HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

GSK 2334470

a PDK1 inhibitor; structure in first source

Also Known As:

GSK-2334470; GSK2334470

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Indazoles: 179
        GSK 2334470: 6
  - Pyrimidines: 510
    - GSK 2334470: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indazoles: 179
      - GSK 2334470: 6

Experts

1.	Yang, Chunmei: 2 articles (06/2018 - 06/2017)
2.	Chen, Xiaohui: 1 article (06/2018)
3.	Zhang, Jin: 1 article (06/2018)
4.	Zhou, Fengping: 1 article (06/2018)
5.	Kim, Chanyang: 1 article (03/2018)
6.	Park, Seungjoon: 1 article (03/2018)
7.	Huang, Xianbo: 1 article (06/2017)
8.	Liu, Hui: 1 article (06/2017)
9.	Qian, Wenbin: 1 article (06/2017)
10.	Wei, Jueying: 1 article (06/2017)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 03/01/2018 - "Furthermore, the protective effects of IGF-1 on oxidative stress and mitochondrial dysfunction were attenuated when cells were preincubated with GSK2334470 or LY294002. "
2.	Neoplasms (Cancer) 12/01/2012 - "Potent PDK1 inhibitors such as GSK2334470 have recently been elaborated as potential anti-cancer agents. " 01/01/2017 - "Ribociclib, in combination with GSK2334470 or the PI3Kα inhibitor alpelisib, decreased xenograft tumor growth more potently than each drug alone. "
3.	Multiple Myeloma 06/01/2018 - "PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein." 06/13/2017 - "PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242."
4.	Neoplasm Metastasis (Metastasis) 08/21/2014 - "Administration of the PDK1 inhibitor GSK2334470 (PDKi) effectively delayed melanomagenesis and metastasis in Braf(V600E)::Pten(-/-) mice. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2017 - "Pharmacologic inhibition of PDK1 with GSK2334470 in combination with ribociclib or palbociclib, another CDK4/6 inhibitor, synergistically inhibited proliferation and increased apoptosis in a panel of ER-positive breast cancer cell lines. "

Related Drugs and Biologics

1.	Insulin-Like Growth Factor I (IGF-1)
2.	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one
3.	Proteasome Inhibitors
4.	PTEN Phosphohydrolase (PTEN Phosphatase)
5.	Mechanistic Target of Rapamycin Complex 1
6.	Alpelisib
7.	PP242
8.	palbociclib
9.	ribociclib