N- (3- methyl- 5- isothiazolyl)- 2- 1- ((3- methyl- 5- isoxazolyl)methyl)- 1H- 3- indolyl- 2- oxoacetamide

01/01/2011 - "BPR0C261 showed in vivo activities against human colorectal, gastric, and nasopharyngeal tumors in nude mice. "
01/01/2011 - "xenografted tumors in nude mice in which the tumor tissue levels of BPR0C261 were found oral dose-dependent. "
01/01/2011 - "BPR0C261 also inhibited the clonogenic growths of cancer cells and showed cytotoxicity against human cervical cancer cells of multidrug-resistant phenotype. "
01/01/2011 - "BPR0C261 is a synthetic small molecule compound cytotoxic against human cancer cells and active prolonging the lifespan of leukemia mice. "
01/01/2011 - "In the present study, we further investigated the mechanisms of its anticancer action and found that BPR0C261 inhibited microtubule polymerization through interacting with the colchicine binding sites on tubulins, disrupted microtubule arrangement and caused cell cycle arrest at G(2)/M phase in cancer cells. "

11/15/2022 - "In this study, we investigated if BPR0C261 could modulate the radiation response of human non-small cell lung cancer (NSCLC) cells with or without p53 expression. "
11/15/2022 - "BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways."

01/01/2011 - "BPR0C261 is a synthetic small molecule compound cytotoxic against human cancer cells and active prolonging the lifespan of leukemia mice. "
01/01/2011 - "Most interestingly, the combination of BPR0C261 plus cisplatin synergistically prolonged the lifespans of mice inoculated with murine leukemia cells. "

01/01/2011 - "BPR0C261 also inhibited the clonogenic growths of cancer cells and showed cytotoxicity against human cervical cancer cells of multidrug-resistant phenotype. "