KS370G
antihyperglycemic; structure in first source
Networked: 3
relevant articles (1 outcomes,
2 trials/studies)
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Bio-Agent Context: Research Results
Experts
Related Diseases
| 1. | Cardiomegaly (Heart Hypertrophy)
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| 2. | Fibrosis (Cirrhosis)
03/05/2015
- " KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice." 07/24/2014
- " In this study, we evaluated the effects of KS370G, a caffeic acid phenylethyl amide, on murine renal fibrosis induced by unilateral renal ischemia-reperfusion injury (IRI) and in TGF-β₁ stimulated renal tubular epithelial cells (NRK52E and HK-2). " 03/05/2015
- " Our results show that KS370G significantly attenuated collagen deposition in the obstructed kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). " 07/24/2014
- " Furthermore, KS370G reverses TGF-β1-induced downregulation of E-cadherin and upregulation of α-SMA and also decreases the expression of fibronectin, collagen I and PAI-1 and inhibits TGF-β₁-induced phosphorylation of Smad2/3. These findings show the beneficial effects of KS370G on renal fibrosis in vivo and in vitro with the possible mechanism being the inhibition of the Smad2/3 signaling pathway."
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| 3. | Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
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| 4. | Reperfusion Injury
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| 5. | Ureteral Obstruction
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