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4- (4- chloro- 2- methylphenoxy)- N- hydroxybutanamide

a c-FLIP inhibitor; structure in first source

Also Known As:

droxinostat

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide: 4
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide: 4

Experts

1.	Ding, Nanhua: 1 article (01/2018)
2.	Fan, Guangqin: 1 article (01/2018)
3.	Hu, Chuan: 1 article (01/2018)
4.	Huang, Ying: 1 article (01/2018)
5.	Kuang, Bohai: 1 article (01/2018)
6.	Shao, Lijian: 1 article (01/2018)
7.	Yang, Wuping: 1 article (01/2018)
8.	Zeng, Huihong: 1 article (01/2018)
9.	Zhang, Yaqiong: 1 article (01/2018)
10.	Ding, Jie: 1 article (02/2016)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 01/01/2018 - "In this study, we examined the effects of droxinostat on the growth of HT-29 colon cancer cells. " 01/01/2018 - "Our findings suggest that the effects of droxinostat on colon cancer cells are mediated by the induction of oxidative stress and apoptotic cell death." 01/01/2018 - "Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress."
2.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "Combination index and isobologram analyses revealed that the horizontal combination of the small molecule 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) along with T-DM1 displayed the strongest synergy for inducing apoptosis in hormone refractory breast cancer cells. " 09/01/2010 - "4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells." 09/01/2010 - "We used a small molecule inhibitor of c-FLIP, 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH), and show that CMH, but not its inactive analog, downregulated c-FLIP(L) and c-FLIP(S) mRNA and protein levels, caused poly(ADP-ribose) polymerase (PARP) degradation, reduced cell survival, and induced apoptosis in MCF-7 breast cancer cells. "
3.	Hepatocellular Carcinoma (Hepatoma) 02/01/2016 - "Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP."

Related Drugs and Biologics

1.	Histone Deacetylase Inhibitors
2.	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
6.	Hormones (Hormone)