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PMX 464

induces Nrf2; structure in first source

Also Known As:

PMX-464; PMX464

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroquinones: 47
        PMX 464: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        PMX 464: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - PMX 464: 3

Experts

1.	Sexton, D W: 1 article (11/2008)
2.	Evans, H: 1 article (08/2007)
3.	Huber, K: 1 article (08/2007)
4.	Lakhani, N: 1 article (08/2007)
5.	Martin, S: 1 article (08/2007)
6.	Mukherjee, A: 1 article (08/2007)
7.	Bradshaw, Tracey D: 1 article (10/2006)
8.	Lion, Cedric J: 1 article (10/2006)
9.	Matthews, Charles S: 1 article (10/2006)
10.	Stevens, Malcolm F G: 1 article (10/2006)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 08/01/2007 - "A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines." 11/01/2008 - "PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, has been investigated in endothelial cells, fibroblasts and colorectal cancer cell lines but in the present issue of the BJP, these investigations were extended to A549 airway epithelial cells. "
2.	Neoplasms (Cancer) 10/01/2006 - "The new compounds were found to be of comparable activity compared to the non-fluorinated precursor PMX 464, in terms of antiproliferative activity in sensitive human cancer cell lines (nanomolar GI(50) values) and inhibitory activity against the thioredoxin signalling system."
3.	Inflammation (Inflammations) 11/01/2008 - "Targeting airway inflammation: PMX464 and the epithelial bulls eye."
4.	Hypoxia (Hypoxemia) 08/01/2007 - "Protein and enzyme assays showed that PMX464, in HT29, inhibited Trx1 function without altering expression and that inhibition correlated with decreased proliferation and survival, and was more marked under hypoxia. "

Related Drugs and Biologics

1.	Thioredoxins
2.	Sulfhydryl Compounds (Thiols)
3.	Proteins (Proteins, Gene)
4.	Hydroquinones
5.	Enzymes