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4'-(1-(((6,7-dichloro-3- oxo- 2,3- dihydro- 4H- 1,4- benzoxazin- 4- yl)acetyl)(methyl)amino)- 2- (4- morpholinyl)ethyl)- 4- biphenylcarboxylic acid

a urotensin-II receptor antagonist; structure in first source

Also Known As:

GSK 1440115; GSK-1440115; GSK1440115

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        4'-(1-(((6,7-dichloro-3- oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(4-morpholinyl)ethyl)-4-biphenylcarboxylic acid: 2
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - 4'-(1-(((6,7-dichloro-3- oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(4-morpholinyl)ethyl)-4-biphenylcarboxylic acid: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Benzoxazines: 58
      - 4'-(1-(((6,7-dichloro-3- oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(4-morpholinyl)ethyl)-4-biphenylcarboxylic acid: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazines: 58
      - 4'-(1-(((6,7-dichloro-3- oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl)(methyl)amino)-2-(4-morpholinyl)ethyl)-4-biphenylcarboxylic acid: 2

Experts

1.	Jung, Yi-Sook: 1 article (05/2017)
2.	Kim, Tae-Ho: 1 article (05/2017)
3.	Kim, Young-Ae: 1 article (05/2017)
4.	Lee, Byung Ho: 1 article (05/2017)
5.	Lee, Dong Gil: 1 article (05/2017)
6.	Yi, Kyu Yang: 1 article (05/2017)
7.	Behm, David J: 1 article (01/2013)
8.	Kumar, Sanjay: 1 article (01/2013)
9.	Mahar, Kelly M: 1 article (01/2013)
10.	Noble, Robert B: 1 article (01/2013)

Related Diseases

1.	Neointima 05/01/2017 - "In this study, we evaluated the effects of a newly synthesized UII receptor (UT) antagonist, KR- 36996, on the proliferation of SMCs in vitro and neointima formation in vivo in comparison with GSK-1440115, a known potent UT antagonist. "
2.	Atherosclerosis 05/01/2017 - "These results suggest that KR-36996 is a better candidate than GSK-1440115 in preventing vascular proliferation in the pathogenesis of atherosclerosis and restenosis."
3.	Bronchial Spasm 01/01/2013 - "While GSK1440115 was safe and well-tolerated, it did not induce bronchodilation in asthmatics, or protect against methacholine-induced bronchospasm, suggesting that acute UT antagonism is not likely to provide benefit as an acute bronchodilator in this patient population."
4.	Asthma (Bronchial Asthma) 01/01/2013 - "Our objective was to test antagonism of the urotensin (UT) receptor by GSK1440115, a novel, competitive, and selective inhibitor of the UT receptor, as a therapeutic strategy for the treatment of asthma. " 01/01/2013 - "Effects of Urotensin II Receptor Antagonist, GSK1440115, in Asthma."

Related Drugs and Biologics

1.	Methacholine Chloride (Methacholine)
2.	Urotensins
3.	Bronchodilator Agents (Bronchodilators)
4.	urotensin II
5.	KR-36996