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methyl antcinate A

an antineoplastic agent isolated from Antrodia camphorata; structure in first source

Also Known As:

methylantcinate A

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - methyl antcinate A: 4

Experts

1.	Tzeng, Yew-Min: 4 articles (02/2013 - 07/2010)
2.	Tsai, Wan-Chi: 3 articles (02/2013 - 10/2010)
3.	Rao, Yerra Koteswara: 3 articles (07/2012 - 07/2010)
4.	Yang, Chi-Chiang: 2 articles (07/2012 - 10/2010)
5.	Geethangili, Madamanchi: 2 articles (10/2010 - 07/2010)
6.	Chang, Wen-Wei: 1 article (02/2013)
7.	Fong, Pin-Chung: 1 article (02/2013)
8.	Peng, Chih-Yu: 1 article (02/2013)
9.	Yu, Cheng-Chia: 1 article (02/2013)
10.	Chen, Dar-Ren: 1 article (07/2012)

Related Diseases

1.	Mouth Neoplasms (Oral Cancer) 10/15/2010 - "Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway." 07/01/2012 - "Among these triterpenoids, methyl antcinate A (MAA) exhibited the most potent spectrum of anticancer effects in KB cells, four different oral cancer cell lines (TSCCa, GNM, OC-2, and OEC-M1), Panc-1, BT474, PC-3, OVCAR-3, HeLa, and U2OS cells with high selectivity indices (CC(50)/IC(50)). " 10/15/2010 - "An ergostane type triterpenoid methylantcinate A (MAA) isolated from the fruiting bodies of Antrodia camphorata inhibited the growth of oral cancer cell lines OEC-M1 and OC-2 in a dose-dependent manner, without cytotoxic to normal oral gingival fibroblast cells. " 02/26/2013 - "Methyl antcinate A (MAA) is an ergostane-type triterpenoid extracted from the fruiting bodies of Antrodia camphorate that has been reported to be a cytotoxic agent towards some types of cancer cells, such as oral cancer and liver cancer. "
2.	Neoplasms (Cancer) 02/26/2013 - "Methyl Antcinate A suppresses the population of cancer stem-like cells in MCF7 human breast cancer cell line." 10/15/2010 - "Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway." 02/26/2013 - "Methyl antcinate A (MAA) is an ergostane-type triterpenoid extracted from the fruiting bodies of Antrodia camphorate that has been reported to be a cytotoxic agent towards some types of cancer cells, such as oral cancer and liver cancer. "
3.	Liver Neoplasms (Liver Cancer) 07/19/2010 - "We investigated the effects of antcin A, antcin C, and methyl antcinate A (MAA) isolated from Antrodia camphorata on the proliferation of human liver cancer cell lines Huh7, HepG2, and Hep3B and the normal cell rat hepatocytes. " 07/19/2010 - "Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway." 02/26/2013 - "Methyl antcinate A (MAA) is an ergostane-type triterpenoid extracted from the fruiting bodies of Antrodia camphorate that has been reported to be a cytotoxic agent towards some types of cancer cells, such as oral cancer and liver cancer. "
4.	Breast Neoplasms (Breast Cancer) 02/26/2013 - "Methyl Antcinate A suppresses the population of cancer stem-like cells in MCF7 human breast cancer cell line."

Related Drugs and Biologics

1.	Triterpenes
2.	ergostane
3.	Actin Depolymerizing Factors (Cofilins)
4.	Oxidants (Oxidizing Agents)
5.	Cytotoxins (Cytolysins)
6.	antcin A