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CA 432

an antineoplastic agent; structure in first source

Also Known As:

CA-432; CA432 cpd

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Greene, Lisa M: 4 articles (02/2013 - 11/2010)
2.	Meegan, Mary J: 4 articles (02/2013 - 11/2010)
3.	Zisterer, Daniela M: 4 articles (02/2013 - 11/2010)
4.	Carr, Miriam: 3 articles (02/2013 - 11/2010)
5.	O'Boyle, Niamh M: 3 articles (02/2013 - 11/2010)
6.	Lawler, Mark: 2 articles (05/2011 - 11/2010)
7.	Hughes, Linda: 1 article (02/2013)
8.	McDonnell, Susan: 1 article (02/2013)
9.	Nathwani, Seema-Maria: 1 article (02/2013)
10.	Nolan, Derek P: 1 article (09/2012)

Related Diseases

1.	Adenocarcinoma 09/01/2012 - "In this report, we demonstrate for the first time that prolonged exposure to CA-4 and an azetidinone cis-restricted analogue, CA-432 (chemical name; 4-(3-Hydroxy-4-methoxyphenyl)-3-phenyl-1-(3,4,5-trimethoxyphenyl)-azetidin-2-one) induced autophagy in adenocarcinoma-derived CT-26, Caco-2 and HT-29 cells but not in fibrosarcoma-derived HT-1080 cells. " 02/01/2013 - "We established that two representative β-lactam compounds, CA-104 and CA-432, exerted both anti-endothelial effects [G2/M arrest and apoptosis of primary human umbilical vein endothelial cells (HUVECs)] and anti-angiogenic effects [inhibition of HUVEC migration and differentiation and reduced vascular endothelial growth factor (VEGF) release from MDA-MB-231 breast adenocarcinoma cells]. "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/01/2010 - "CA-432 induced rapid apoptosis in HL-60 acute myeloid leukemia cells, which was accompanied by depolymerization of the microtubular network, poly(ADP-ribose) polymerase cleavage, caspase-3 activation, and Bcl-2 cleavage. "
3.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/01/2010 - "The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance."
4.	Fibrosarcoma 09/01/2012 - "In this report, we demonstrate for the first time that prolonged exposure to CA-4 and an azetidinone cis-restricted analogue, CA-432 (chemical name; 4-(3-Hydroxy-4-methoxyphenyl)-3-phenyl-1-(3,4,5-trimethoxyphenyl)-azetidin-2-one) induced autophagy in adenocarcinoma-derived CT-26, Caco-2 and HT-29 cells but not in fibrosarcoma-derived HT-1080 cells. "
5.	Carcinoma (Carcinomatosis) 05/01/2011 - "We demonstrate that CA-4 and CA-432 depolymerise the microtubular network of human cervical carcinoma-derived cells. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	beta-Lactams
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
5.	Lactams
6.	CA-104
7.	2-azetidinone