2,2'-dihydroxychalcone

an antineoplastic agent; structure in first source

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 05/01/2009 - "In mechanistic studies, the most potent chalcone, 2,2'-dihydroxychalcone could induce G2/M arrest and then apoptosis of the cancer cells. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2010 - "Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 10/15/2010 - "The hydroxychalcones, 2',5'-dihydroxychalcone (D-601) and 2,2'-dihydroxychalcone (D-501), were found to activate heat shock factor 1 (Hsf1) and exhibited radiation sensitization properties in colon and pancreatic cancer cells. "
4.	Colonic Neoplasms (Colon Cancer) 07/01/2008 - "2,2'-Dihydroxychalcone, a glutathione transferase inhibitor, sensitises human colon adenocarcinoma cells to chlorambucil and melphalan, but not to actinomycin D."

1.	Chalcone (Benzalacetophenone)
2.	Melphalan (Alkeran)
3.	Glutathione Transferase (Glutathione S-Transferase)
4.	Flavonoids
5.	Dactinomycin (Actinomycin)
6.	Chlorambucil (Leukeran)
7.	2',5'-dihydroxychalcone
8.	fisetin