gukulenin A

cytotoxic terpene from the marine sponge Phorbas gukulensis; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Ovarian Neoplasms (Ovarian Cancer) 02/21/2019 - "In this study, we examined the anticancer activities of gukulenin A in ovarian cancer cell lines (A2780, SKOV3, OVCAR-3, and TOV-21G) and in an ovarian cancer mouse model generated by injecting A2780 cells. " 02/21/2019 - "The results suggest that gukulenin A may be a potential therapeutic agent for ovarian cancer." 02/21/2019 - "Gukulenin A markedly inhibited cell viability in four ovarian cancer cell lines, including the A2780 cell line. " 02/21/2019 - "Gukulenin A treatment increased the fraction of cells accumulated at the sub G1 phase in a dose-dependent manner and the population of annexin V-positive cells, suggesting that gukulenin A induces apoptotic cell death in ovarian cancer cells. "
2.	Neoplasms (Cancer) 02/21/2019 - "We found that gukulenin A suppressed tumor growth in A2780-bearing mice. "

1.	Annexin A5