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tubulysin B

from myxobacteria culture broth; structure in first source

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - tubulysin B: 12
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Pipecolic Acids
      - tubulysin B: 12
- Heterocyclic Acids
  - Pipecolic Acids
    - tubulysin B: 12

Experts

1.	Low, Philip S: 5 articles (01/2020 - 07/2015)
2.	Leamon, Christopher P: 5 articles (01/2019 - 12/2008)
3.	Reddy, Joseph A: 5 articles (01/2019 - 12/2008)
4.	Roy, Jyoti: 4 articles (01/2020 - 07/2015)
5.	Dorton, Ryan: 4 articles (01/2019 - 12/2008)
6.	Vetzel, Marilynn: 4 articles (01/2019 - 12/2008)
7.	Vlahov, Iontcho R: 3 articles (01/2019 - 09/2009)
8.	Klein, Patrick J: 3 articles (06/2017 - 09/2009)
9.	Wang, Yu: 3 articles (06/2017 - 12/2008)
10.	Westrick, Elaine: 3 articles (06/2017 - 12/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Finally, systemic administration of a tubulysin B conjugate of FL promoted complete eradication of solid tumors with no evidence of gross toxicity to the animals. " 01/01/2019 - "In contrast, the nontargeted tubulysin B drug proved to be inactive against the LNCaP tumor model when administered at doses near to or greater than the maximum tolerated level. " 01/01/2019 - "Herein, we report on the construction and biological testing of novel tubulysin B-containing therapeutic agents for the treatment of PSMA-expressing cancer. " 01/01/2018 - "A small molecule CAIX-targeted tubulysin B conjugate was then synthesized and examined for its ability to kill CAIX-expressing tumor cells in vitro. " 07/25/2017 - "Structural recognition of tubulysin B derivatives by multidrug resistance efflux transporters in human cancer cells."
2.	Breast Neoplasms (Breast Cancer) 07/25/2017 - "Herein we explored the cytotoxic activity of synthetic tubulysin B (Tub-B, EC1009) derivatives (Tub-B-hydrazide/EC0347 and Tub-B bis-ether/EC1820), and their recognition by the MDR efflux transporters P-glycoprotein 1 (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP). "

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