3- (6- isobutyl- 9- methoxy- 1,4- dioxo- 1,2,3,4,6,7,12,12a- octahydropyrazino(1',2'- 1,6)pyrido(3,4- b)indol- 3- yl)propionic acid tert-butyl ester

a breast cancer resistance protein (BCRP) inhibitor; structure in first source

Also Known As:

Ko 143; Ko-143; Ko143 cpd; tert-butyl-3-(6-isobutyl-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propanoate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Castillo, Ana Fernanda: 1 article (01/2019)
2.	Maloberti, Paula Mariana: 1 article (01/2019)
3.	Medrano, Mayra Agustina Ríos: 1 article (01/2019)
4.	Orlando, Ulises Daniel: 1 article (01/2019)
5.	Podesta, Ernesto Jorge: 1 article (01/2019)
6.	Solano, Angela Rosaria: 1 article (01/2019)
7.	Ho, Qin Shi: 1 article (01/2016)
8.	Lim, Hwee Ying: 1 article (01/2016)
9.	Wong, Kim Ping: 1 article (01/2016)

1.	Neoplasms (Cancer) 01/01/2019 - "Further cell survival assays in the presence of Ko 143 and Ceefourin 1, inhibitors of ABCG2 and ABCC4, respectively, upon chemotherapeutic treatment showed greater participation of ABCG2 in anti-cancer drug resistance in cells overexpressing ACSL4. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "3. Using Ko-143, a specific inhibitor of breast cancer resistance protein (BCRP), an ATP-binding cassette (ABC) transporter, we identified this transporter to be responsible for the efflux of p-cresol sulfate, harmol sulfate and the glutathione conjugate of 1-chloro-2,4-dinitrobenzene. "

1.	ATP-Binding Cassette Transporters (ABC Transporters)
2.	Proteins (Proteins, Gene)
3.	Glutathione (Reduced Glutathione)
4.	Dinitrochlorobenzene (DNCB)
5.	Adenosine Triphosphate (ATP)
6.	4-cresol sulfate
7.	harmol sulfate
8.	ceefourin 1