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3- (9- methoxy- 5,11- dimethylpyrido(4,3- b)carbazol- 6- yl)propan- 1- amine
has antineoplastic activity; structure in first source
Also Known As:
NSC 176327; NSC-176327; NSC176327
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Ellipticines: 10
3-(9-methoxy-5,11-dimethylpyrido(4,3-b)carbazol-6-yl)propan-1-amine: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Ellipticines: 10
3-(9-methoxy-5,11-dimethylpyrido(4,3-b)carbazol-6-yl)propan-1-amine: 1
Carbazoles: 32
Ellipticines: 10
3-(9-methoxy-5,11-dimethylpyrido(4,3-b)carbazol-6-yl)propan-1-amine: 1
Indolizines: 3
Indolizidines: 2
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Ellipticines: 10
3-(9-methoxy-5,11-dimethylpyrido(4,3-b)carbazol-6-yl)propan-1-amine: 1
3-Ring Heterocyclic Compounds
Carbazoles: 32
Ellipticines: 10
3-(9-methoxy-5,11-dimethylpyrido(4,3-b)carbazol-6-yl)propan-1-amine: 1
Experts
1.
El-Deiry, Wafik S
: 1 article (12/2008)
2.
Lu, Chao
: 1 article (12/2008)
3.
Wang, Wenge
: 1 article (12/2008)
Related Diseases
1.
Neoplasms (Cancer)
12/01/2008 - "
These results demonstrate an important role of p73 in the anti-tumor effects of NSC176327,and suggest that a close analogue of ellipticine may act by a non-genotoxic mechanism targeting the p53/p73 pathway as compared to the original parent compound that targets the same pathway.
"
12/01/2008 - "
NSC176327 was more potent at inhibiting tumor cell growth as compared to chemotherapeutic drugs and other ellipticine derivatives and induced cell cycle arrest and apoptosis.
"
12/01/2008 - "
Here we further examined the anti-tumor effects of selected compounds in vitro and showed that NSC176327, a derivative of the cytotoxic plant alkaloid ellipticine, exhibited strong anti-neoplastic effect sin wild-type p53, p53-mutant or p53-deficient human colon cancer cells.
"
12/01/2008 - "
Surprisingly, unlike what is observed with the parent compound ellipticine, a DNA damage signaling response was not observed with NSC176327 as evidenced by lack of phosphorylated histone H2AX foci in NSC176327-treated tumor cells.
"
2.
Colonic Neoplasms (Colon Cancer)
12/01/2008 - "
Here we further examined the anti-tumor effects of selected compounds in vitro and showed that NSC176327, a derivative of the cytotoxic plant alkaloid ellipticine, exhibited strong anti-neoplastic effect sin wild-type p53, p53-mutant or p53-deficient human colon cancer cells.
"
3.
Carcinoma (Carcinomatosis)
12/01/2008 - "
Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73.
"
Related Drugs and Biologics
1.
A-Form DNA (A-DNA)
2.
Histones (Histone)
3.
Alkaloids
4.
ellipticine