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poly(lactic acid)-block-polyethylene glycol-folate
Also Known As:
PLLA-b-PEG-folate; poly(L-lactic acid)-block-polyethylene glycol-folate
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Macromolecular Substances: 97
Polymers: 13051
Polyethylene Glycols: 3865
poly(lactic acid)-block-polyethylene glycol-folate: 1
Polyesters: 921
poly(lactic acid)-block-polyethylene glycol-folate: 1
Biomedical and Dental Materials
Polymers: 13051
Polyethylene Glycols: 3865
poly(lactic acid)-block-polyethylene glycol-folate: 1
Polyesters: 921
poly(lactic acid)-block-polyethylene glycol-folate: 1
Technology, Industry, and Agriculture
Manufactured Materials
Biomedical and Dental Materials
Polymers: 13051
Polyethylene Glycols: 3865
poly(lactic acid)-block-polyethylene glycol-folate: 1
Polyesters: 921
poly(lactic acid)-block-polyethylene glycol-folate: 1
Organic Chemicals: 133
Alcohols: 595
Glycols: 38
Ethylene Glycols: 8
Polyethylene Glycols: 3865
poly(lactic acid)-block-polyethylene glycol-folate: 1
Experts
1.
Bae, You Han
: 1 article (11/2008)
2.
Gao, Zhong Gao
: 1 article (11/2008)
3.
Kim, Dongin
: 1 article (11/2008)
4.
Lee, Eun Seong
: 1 article (11/2008)
5.
Oh, Kyung Taek
: 1 article (11/2008)
Related Diseases
1.
Neoplasms (Cancer)
11/01/2008 - "
A mixed-micelle system composed of poly(His-co-Phe (16 mole%))-b-PEG (80 wt%) and PLLA-b-PEG-folate (20 wt%) is selected to target early endosomal pH. DOX-loaded micelles effectively kill both wild-type sensitive (A2780) and DOX-resistant ovarian MDR cancer-cell lines (A2780/DOX(R)) through an instantaneous high dose of DOX in the cytosol, which results from active internalization, accelerated DOX release triggered by endosomal pH, and an endosomal membrance disruption.
"
Related Drugs and Biologics
1.
Micelles