5- hydroxy- 3,6,7,8,3',4'- hexamethoxyflavone

has antineoplastic activity; structure in first source

Also Known As:

2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one; 5-OH-HxMF; 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: 10

Experts

1.	Ho, Chi-Tang: 9 articles (03/2015 - 12/2006)
2.	Li, Shiming: 7 articles (10/2011 - 12/2006)
3.	Pan, Min-Hsiung: 5 articles (10/2011 - 06/2007)
4.	Xiao, Hang: 4 articles (10/2011 - 03/2009)
5.	Dong, Ping: 3 articles (10/2011 - 07/2010)
6.	Guan, Huashi: 3 articles (10/2011 - 07/2010)
7.	McClements, David Julian: 3 articles (10/2011 - 07/2010)
8.	Qiu, Peiju: 3 articles (10/2011 - 07/2010)
9.	Lai, Ching-Shu: 2 articles (12/2007 - 06/2007)
10.	Lo, Chih-Yu: 2 articles (12/2007 - 06/2007)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/23/2006 - "The treatment of MCF-7 breast cancer cells with 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF) and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone (3'-OH-TtMF) induced a sustained increase in concentration of intracellular Ca(2+) ([Ca(2+)](i)) resulting from both depletion of the endoplasmic reticulum Ca(2+) stores and Ca(2+) influx from the extracellular space. " 03/11/2015 - "The present study evaluated the cytotoxic effects of five phytochemicals including 6-gingerol (6-G), 6-shogaol (6-S), 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-HF), nobiletin (NOL), and pterostilbene (PTE) on MCF-7 breast cancer cells and BCSCs. "
2.	Colonic Neoplasms (Colon Cancer) 10/01/2011 - "Previously, we reported that 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF), a polymethoxyflavone found in citrus peels, potently inhibited the growth of multiple human colon cancer cells. " 10/01/2011 - "The inhibitory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on human colon cancer cells." 04/01/2011 - "Previously, we reported that 5-hydroxy polymethoxyflavones (5OH-PMFs) isolated from orange, namely 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5HHMF) and 5-hydroxy-6,7,8,4'-tetramethoxyflavone (5HTMF), potently induced apoptosis and cell-cycle arrest in multiple human colon cancer cells. " 07/01/2010 - "We studied the effects of three major 5-hydroxy PMFs, namely: 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, and 5-hydroxy-6,7,8,4'-tetramethoxyflavone, on human colon cancer HCT116 and HT29 cells. "
3.	Neoplasms (Cancer) 12/01/2007 - "Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice." 06/27/2007 - "Here, we report that 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone (5-OH-HxMF) induces growth inhibition of human cancer cells and induction of apoptosis in HL-60 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). " 12/01/2007 - "Furthermore, 5-OH-HxMF significantly inhibited 7,12-dimethylbenz[a]anthracene/TPA-induced skin tumor formation by reducing the tumor incidence and tumor multiplicity of papillomas at 20 weeks. "
4.	Carcinogenesis 12/01/2007 - "Therefore, all these results revealed for the first time that 5-OH-HxMF is an effective antitumor agent and its inhibitory effect is through the down-regulation of inflammatory iNOS and COX-2 gene expression in mouse skin, suggesting that 5-OH-HxMF is a novel functional agent capable of preventing inflammation-associated tumorigenesis."
5.	Stomach Neoplasms (Stomach Cancer) 10/01/2016 - "5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, a polymethoxyflavone, exerts antitumor effect on PI3K/Akt signaling pathway in human gastric cancer cell BGC-7901."

Related Drugs and Biologics

1.	nobiletin
2.	Phytochemicals
3.	pterostilbene
4.	shogaol
5.	gingerol
6.	5-hydroxy-6,7,8,4'-tetramethoxyflavone
7.	5- hydroxy- 6,7,8,3',4'- pentamethoxyflavone
8.	Caspases
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Antineoplastic Agents (Antineoplastics)