nifene

a nicotinic alpha4beta2 receptor imaging agent; structure in first source

Also Known As:

18F-nifene; 2-(18F)fluoro-3-(2-(3-pyrrolinyl)methoxy)pyridine; 2-fluoro-3-(2-(3-pyrrolinyl)methoxy)pyridine

Networked: 4 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - nifene: 4
  - Pyridines: 88
    - nifene: 4

Experts

1.	Campoy, Anthony-David T: 1 article (12/2021)
2.	Ladwa, Reisha M: 1 article (12/2021)
3.	Liang, Christopher: 1 article (12/2021)
4.	Mukherjee, Jogeshwar: 1 article (12/2021)
5.	Patel, Ishani H: 1 article (12/2021)
6.	Patel, Krystal K: 1 article (12/2021)
7.	Chernyavsky, A I: 1 article (06/2013)
8.	Corches, A: 1 article (06/2013)
9.	Galitovskiy, V: 1 article (06/2013)
10.	Grando, S A: 1 article (06/2013)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 12/04/2021 - "We report [18F]nifene binding to α4β2* nicotinic acetylcholinergic receptors (nAChRs) in Parkinson's disease (PD). " 12/04/2021 - "[18F]Nifene PET/CT Imaging in Mice: Improved Methods and Preliminary Studies of α4β2* Nicotinic Acetylcholinergic Receptors in Transgenic A53T Mouse Model of α-Synucleinopathy and Post-Mortem Human Parkinson's Disease."
2.	Synucleinopathies 12/04/2021 - "[18F]Nifene PET/CT Imaging in Mice: Improved Methods and Preliminary Studies of α4β2* Nicotinic Acetylcholinergic Receptors in Transgenic A53T Mouse Model of α-Synucleinopathy and Post-Mortem Human Parkinson's Disease."
3.	Tobacco Use Disorder (Nicotine Dependence) 10/24/2023 - "We conclude that using an image-derived input function for kinetic modeling of nicotinic PET ligands provides suitable results compared to reference tissue-based methods and that the chemical properties of 2-FA and Nifene are suitable to study receptor response to nicotine addiction and smoking cessation therapies."
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2023 - "Abnormal [18 F]NIFENE binding in transgenic 5xFAD mouse model of Alzheimer's disease: In vivo PET/CT imaging studies of α4β2* nicotinic acetylcholinergic receptors and in vitro correlations with Aβ plaques."
5.	Neoplasms (Cancer) 06/01/2013 - "The tumor/nontumor ratios for 18F-FDG were lower than for 18F-Nifene. " 06/01/2013 - "Quantitative analysis of the extent and amount of 18F-Nifene binding in lung in vivo and ex vivo demonstrated a higher tumor/nontumor ratio due to selective labeling of tumor nodules expressing abundant α4 nicotinic receptor subunits. "

Related Drugs and Biologics

1.	Ligands
2.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)
3.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)

Related Therapies and Procedures

1.	Therapeutics