FR260330

an inducible nitric oxide synthase inhibitor

Also Known As:

(2E)-3-(4-chlorophenyl)-N-((1S)-2-oxo-2-((2-oxo-2-(4-((6-(trifluoromethyl)-4-pyrimidinyl)oxy)-1-piperidinyl)ethyl)amino)-1-(2-pyridinylmethyl)ethyl)acrylamide

Networked: 3 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - FR260330: 3

Experts

1.	Chida, Noboru: 2 articles (02/2006 - 02/2005)
2.	Sudo, Yuji: 2 articles (02/2006 - 02/2005)
3.	Tamura, Kouichi: 2 articles (02/2006 - 02/2005)
4.	Hirata, Koichi: 1 article (11/2007)
5.	Isobe, Masato: 1 article (11/2007)
6.	Katsuramaki, Tadashi: 1 article (11/2007)
7.	Kikuchi, Hitoshi: 1 article (11/2007)
8.	Kukita, Kazuma: 1 article (11/2007)
9.	Meguro, Makoto: 1 article (11/2007)
10.	Mizuguchi, Toru: 1 article (11/2007)

Related Diseases

1.	Fibrosis (Cirrhosis) 11/01/2007 - "After 12 weeks of treatment with FR260330, the rats showed inhibition of progressions of cirrhosis, ascites, and splenomegaly as well as a significant reduction in the proportions of connective tissue in the liver. " 11/01/2007 - "The present study demonstrates that FR260330 reduces liver fibrosis by the inhibition of transforming growth factor-beta1 and retards the development of cirrhosis. "
2.	Splenomegaly 11/01/2007 - "After 12 weeks of treatment with FR260330, the rats showed inhibition of progressions of cirrhosis, ascites, and splenomegaly as well as a significant reduction in the proportions of connective tissue in the liver. "
3.	Ascites 11/01/2007 - "After 12 weeks of treatment with FR260330, the rats showed inhibition of progressions of cirrhosis, ascites, and splenomegaly as well as a significant reduction in the proportions of connective tissue in the liver. "
4.	Liver Cirrhosis (Hepatic Cirrhosis) 11/01/2007 - "The present study demonstrates that FR260330 reduces liver fibrosis by the inhibition of transforming growth factor-beta1 and retards the development of cirrhosis. "
5.	Ischemia 02/27/2006 - "In this study, the effect of FR260330 in the prevention of renal I/R injury was evaluated in the model of one kidney ischemia in Vervet monkeys. " 02/27/2006 - "Transient (60 min) left renal ischemia was produced by simultaneous contralateral nephrectomy in treated (FR260330 20 mg/kg/day) and placebo control groups. "

Related Drugs and Biologics

1.	Transforming Growth Factor beta1 (TGF beta 1)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)

Related Therapies and Procedures

1.	Therapeutics
2.	Nephrectomy
3.	Oral Administration