HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

noviose

is a key synthon for the construction of novobiocin, a clinically useful antitumor agent; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Sugars: 11126
  - Monosaccharides: 889
    - noviose: 4

Experts

1.	Blagg, Brian S J: 2 articles (12/2011 - 07/2010)
2.	Kusuma, Bhaskar Reddy: 2 articles (12/2011 - 07/2010)
3.	Alami, Mouâd: 2 articles (02/2009 - 04/2008)
4.	Brion, Jean-Daniel: 2 articles (02/2009 - 04/2008)
5.	Le Bras, Gaëlle: 2 articles (02/2009 - 04/2008)
6.	Marsaud, Véronique: 2 articles (02/2009 - 04/2008)
7.	Messaoudi, Samir: 2 articles (02/2009 - 04/2008)
8.	Peyrat, Jean-François: 2 articles (02/2009 - 04/2008)
9.	Radanyi, Christine: 2 articles (02/2009 - 04/2008)
10.	Renoir, Jack-Michel: 2 articles (02/2009 - 04/2008)

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

12/01/2011 - "Replacement of the synthetically complex noviose sugar with simple aromatic side chains produced analogs that maintain moderate cytotoxic activity against MCF7 and SkBR3 breast cancer cell-lines. "
07/13/2010 - "Evaluation against two breast cancer cell lines demonstrated that replacement of the stereochemical complex noviose with simplified alkyl amines increased anti-proliferative activity, resulting in novobiocin analogues that manifest IC(50) values in the mid nanomolar range."
02/08/2009 - "Removal of the noviose moiety in novobiocin and introduction of a tosyl substituent at C-4 or C-7 coumarin nucleus provided derivatives 4TCNA and 7TCNA which compared favourably with novobiocin in MCF-7 breast cancer cells. "
04/01/2008 - "A new series of coumarin inhibitors of hsp90 lacking the noviose moiety as well as substituents on C-7 and C-8 positions of the aromatic ring was synthesised and their hsp90 inhibitory activity has been delineated: for example, their capacity to induce the degradation of client proteins and to inhibit estradiol-induced transcription in human breast cancer cells. "

Related Drugs and Biologics

1.	Novobiocin (Streptonivicin)
2.	coumarin
3.	Proteins (Proteins, Gene)
4.	Estradiol (Delestrogen)
5.	Amines
6.	Sugars