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CT52923

structure in first source

Also Known As:

(((2H)-benzo(d)1,3-dioxalan-5-ylmethyl)amino)((6,7-dimethoxyquinazolin-4-yl)piperazinyl)methane-1-thione; CT 52923

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - CT52923: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - CT52923: 2

Experts

1.	Giese, Neill A: 1 article (07/2002)
2.	Hollenbach, Stanley J: 1 article (07/2002)
3.	Israel, Mark A: 1 article (07/2002)
4.	Lokker, Nathalie A: 1 article (07/2002)
5.	Sullivan, Carol M: 1 article (07/2002)
6.	Apatira, M: 1 article (09/2001)
7.	Betz, A: 1 article (09/2001)
8.	Giese, N A: 1 article (09/2001)
9.	Hollenbach, S: 1 article (09/2001)
10.	Ide , S: 1 article (09/2001)

Related Diseases

1.	Neointima 09/01/2001 - "To investigate the effect of CT52923 on PDGFR signaling, in vivo studies demonstrated that CT52923 could significantly inhibit neointima formation following carotid artery injury by oral administration in the rat. " 09/01/2001 - "Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury."
2.	Vascular System Injuries 09/01/2001 - "Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury."
3.	Carotid Artery Injuries 09/01/2001 - "To investigate the effect of CT52923 on PDGFR signaling, in vivo studies demonstrated that CT52923 could significantly inhibit neointima formation following carotid artery injury by oral administration in the rat. "
4.	Neoplasms (Cancer) 07/01/2002 - "administration of CT52923 to nude mice caused a significant 61% reduction (P < 0.006) in tumor growth of NIH/3T3 cells transformed by PDGF, whereas tumor formation by cells expressing v-fms was unaffected. "
5.	Glioma (Gliomas) 07/01/2002 - "More importantly, treatment with the PDGFR antagonist CT52923 inhibited survival and/or mitogenic pathways in all of the glioblastoma cell lines tested and prevented glioma formation in a nude mouse xenograft model. "

Related Drugs and Biologics

1.	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)

Related Therapies and Procedures

1.	Oral Administration