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1- hydroxy- 4- (1- naphthyl)- 6- octylpiperidine- 2- one
structure in first osurce
Also Known As:
BMD 188; BMD-188; BMD188
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Hydroxylamines: 16
Hydroxamic Acids: 239
1-hydroxy-4-(1-naphthyl)-6-octylpiperidine-2-one: 3
Carboxylic Acids: 973
Hydroxy Acids: 94
Hydroxamic Acids: 239
1-hydroxy-4-(1-naphthyl)-6-octylpiperidine-2-one: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperidines: 17
Piperidones: 37
1-hydroxy-4-(1-naphthyl)-6-octylpiperidine-2-one: 3
Related Diseases
1.
Prostatic Neoplasms (Prostate Cancer)
01/01/1999 - "
Collectively, the preceding in vitro and the current in vivo studies suggest that BMD188 and its analogs may find clinical applications in the treatment of prostate cancer patients by inducing apoptotic death of prostate cancer cells.
"
09/01/1999 - "
The lead compound, termed BMD188, induces programmed cell death in a variety of prostate cancer cells in vitro as well as in vivo (L.
"
01/01/1999 - "
administered BMD188 significantly inhibited the primary growth and local invasion of Du145 prostate cancer cells orthotopically implanted into SCID or athymic nude mice.
"
01/01/1999 - "
administered BMD188, were performed in SCID mice or athymic nude mice which had been orthotopically transplanted with Du145 human prostate cancer cells.
"
01/01/1999 - "
In the accompanying paper, we show that BMD188 also inhibits the primary growth and local invasion of Du145 prostate cancer cells orthotopically implanted into the SCID or athymic nude mice.
"
2.
Neoplasms (Cancer)
01/01/1999 - "
The tumor-inhibitory effect of BMD188 was due to apoptosis induction in vivo, as revealed by histological analysis as well as TUNEL staining of the tumor tissue sections.
"
01/01/1999 - "
Furthermore, unlike the above drugs, BMD188 could induce 100% apoptosis in tumor cells.
"
Related Drugs and Biologics
1.
Hydroxamic Acids (Hydroxamic Acid)
2.
Androgens
3.
Caspases
4.
Fatty Acids (Saturated Fatty Acids)
5.
Arachidonate 12-Lipoxygenase (12 Lipoxygenase)