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poly(trans- 1,2- diaminocyclohexane)platinum- carboxyamylose
Also Known As:
poly-plat
Networked:
2
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Organometallic Compounds: 64
Organoplatinum Compounds
poly(trans-1,2-diaminocyclohexane)platinum-carboxyamylose: 2
Experts
1.
Aggarwal, Surinder K
: 1 article (07/2002)
2.
Telgenhoff, Dale J
: 1 article (07/2002)
3.
Aggarwal, S K
: 1 article (07/2000)
4.
Burkitt, K
: 1 article (07/2000)
Related Diseases
1.
Teratocarcinoma
07/01/2000 - "
Murine peritoneal macrophages, human fibroblasts and human ovarian teratocarcinoma cells were treated with CDDP (10 micrograms/ml) and "poly-plat" (10 micrograms/ml) for 2 h and cultured for 2-96 h.
"
07/01/2000 - "
Based on our studies, we propose that "poly-plat" is more effective in activation of the macrophages and human fibroblasts in terms of IL-2, but not so with human ovarian teratocarcinoma cells.
"
07/01/2000 - "
However, human ovarian teratocarcinoma cells didn't show any significant increase in IL-2 levels after "poly-plat" treatment and there was instead a decrease of 15% in cell numbers at 8 h.
"
2.
Neoplasms (Cancer)
07/01/2002 - "
These results demonstrate the ability of Poly-Plat to arrest the growth of tumor cells and activate macrophages to induce apoptosis in the cell lines tested.
"
07/01/2002 - "
Action of Cisplatin (cis-dichlorodiammine platinum II) and Poly-Plat [poly-[(trans-1,2-diaminocyclohexane) pla-tinum]-carboxyamylose] on tumor cells was examined using human fibrosarcoma (HT1080) and Walker rat carcinoma (WRC-256) in culture.
"
3.
Fibrosarcoma
07/01/2002 - "
Action of Cisplatin (cis-dichlorodiammine platinum II) and Poly-Plat [poly-[(trans-1,2-diaminocyclohexane) pla-tinum]-carboxyamylose] on tumor cells was examined using human fibrosarcoma (HT1080) and Walker rat carcinoma (WRC-256) in culture.
"
4.
Carcinoma (Carcinomatosis)
07/01/2002 - "
Action of Cisplatin (cis-dichlorodiammine platinum II) and Poly-Plat [poly-[(trans-1,2-diaminocyclohexane) pla-tinum]-carboxyamylose] on tumor cells was examined using human fibrosarcoma (HT1080) and Walker rat carcinoma (WRC-256) in culture.
"
Related Drugs and Biologics
1.
Interleukin-2 (IL2)
2.
Platinum
3.
Cisplatin (Platino)