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cryptdin 3

enteric defensin that promotes channel formation; amino acid sequence in first source

Also Known As:

cryptdin-3

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Pore Forming Cytotoxic Proteins
      - Antimicrobial Cationic Peptides: 414
        Defensins: 1422
        cryptdin 3: 2
- Peptides: 82426
  - Antimicrobial Peptides: 3727
    - Antimicrobial Cationic Peptides: 414
      - Defensins: 1422
        cryptdin 3: 2
  - Antimicrobial Cationic Peptides: 414
    - Defensins: 1422
      - cryptdin 3: 2

Experts

1.	Eaton, Douglas C: 1 article (05/2002)
2.	Lencer, Wayne I: 1 article (05/2002)
3.	Madara, James L: 1 article (05/2002)
4.	Merlin, Didier: 1 article (05/2002)
5.	Selsted, Michael E: 1 article (05/2002)
6.	Yue, Gang: 1 article (05/2002)
7.	Lencer, W I: 1 article (02/2001)
8.	Madara, J L: 1 article (02/2001)
9.	Merlin, D: 1 article (02/2001)
10.	Selsted, M E: 1 article (02/2001)

Related Diseases

1.

Cystic Fibrosis (Mucoviscidosis)

02/01/2001 - "Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia."
02/01/2001 - "Cryptdin-3 induces a current in basolaterally permeabilized epithelial monolayers derived from airway cells harboring the deltaF508 mutation of cystic fibrosis (CF; deltaG(ap) = 0.80 +/- 0.06 mS/cm2), demonstrating that cryptdin-3 restores anion secretion in CF cells; this occurs independently of the CF transmembrane conductance regulator channel. "
05/01/2002 - "Recent work with short-circuit current measurements indicated that at least one cryptdin peptide, cryptdin 3, induces apical conductance(s) in Cl(-) secretory, including cystic fibrosis, epithelia. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Anions
3.	cryptdin