human KISS1 protein

RefSeq NM_002256

Also Known As:

KISS1 protein, human; KiSS-1 metastasis-suppressor protein, human; KiSS-1 protein, human; Kp-10 peptide; kisspeptin, human; kisspeptin-10; kisspeptin-10 protein, human; kisspeptin-13 protein, human; kisspeptin-14 protein, human; kisspeptin-54, human; malignant melanoma metastasis-suppressor protein, human; metastin protein, human

Networked: 37 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - Kisspeptins: 865
        human KISS1 protein: 37
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kisspeptins: 865
      - human KISS1 protein: 37
  - Neuropeptides: 6772
    - Kisspeptins: 865
      - human KISS1 protein: 37

Experts

1.	Millar, Robert P: 3 articles (11/2017 - 12/2009)
2.	Liu, Mingyao: 2 articles (01/2022 - 09/2009)
3.	Hamdan, Farqad B: 2 articles (04/2020 - 12/2016)
4.	Sato, Kengo: 2 articles (01/2020 - 04/2017)
5.	Watanabe, Takuya: 2 articles (01/2020 - 04/2017)
6.	Tena-Sempere, Manuel: 2 articles (01/2018 - 07/2013)
7.	Anderson, Richard A: 2 articles (11/2017 - 07/2013)
8.	Babwah, Andy V: 2 articles (03/2016 - 01/2011)
9.	Bhattacharya, Moshmi: 2 articles (03/2016 - 01/2011)
10.	Song, Guo-Qing: 2 articles (01/2016 - 02/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Accordingly, administration of kisspeptin-10 significantly impairs T cell function, whereas knockout of Gpr54 in T cells inhibits lung tumor progression by suppressing T cell dysfunction and exhaustion with or without AR. " 01/01/2018 - "Interestingly, Kisspeptin-10 (KP-10), the smallest active form of kisspeptin also stimulates cancer cell invasive behavior through activation of MAPK/Erk pathway. " 01/01/2015 - "In this study we investigated effects of kisspeptin-10, the most potent member of kisspeptin family, on Migration and proliferation of endothelial cells that are necessary for angiogenesis and tumor metastasis. " 01/01/2018 - "Kisspeptin-10 (KP-10) acts as a tumor metastasis suppressor via its receptor, G-protein-coupled receptor 54 (GPR54). " 09/01/2009 - "Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation."
2.	Neoplasm Metastasis (Metastasis) 01/01/2015 - "In this study we investigated effects of kisspeptin-10, the most potent member of kisspeptin family, on Migration and proliferation of endothelial cells that are necessary for angiogenesis and tumor metastasis. " 01/01/2022 - "KiSS-1, first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10. " 01/01/2018 - "Kisspeptin-10 (KP-10) acts as a tumor metastasis suppressor via its receptor, G-protein-coupled receptor 54 (GPR54). " 10/01/2013 - "The Kiss-1 gene, initially described as a suppressor of metastasis in malignant melanoma, encodes the Kiss-1 protein which can be processed to other peptides, e.g., Kisspeptin-10, Kisspeptin-13, Kisspeptin-14 and Kisspeptin-54. " 09/01/2009 - "Kisspeptin-10 (Kp-10), a decapeptide derived from the primary translation product of KISS1 gene, has been reported previously to be a key hormone for puberty and an inhibitor for tumor metastasis via the activation of G protein-coupled receptor 54. "
3.	Pre-Eclampsia (Preeclampsia) 12/01/2016 - "This study aims to evaluate the role of kisspeptin-10 in preeclampsia and check for possible relationship between its severity and fetal growth well-being. " 04/01/2020 - "Kisspeptin-10 levels were reduced in preeclampsia (PE) women compared with normotensive pregnancies. " 12/01/2016 - "Kisspeptin-10 level was directly related to the resistance index in the second trimester in patients with severe preeclampsia, while it inversely correlated with the systolic/diastolic ratio and resistance index in the third trimester in patients with mild preeclampsia. " 12/01/2016 - "Kisspeptin-10 level is useful in assessing the severity of preeclampsia and can be a novel marker downregulated in pregnant women with preeclampsia, especially in those who also developed impaired uteroplacental perfusion or intrauterine growth restriction." 04/01/2020 - "To evaluate plasma kisspeptin-10 (KP-10) as a marker for preeclampsia and assess its relation to altered reproductive hormones in preeclamptic pregnant women. "
4.	Ovarian Hyperstimulation Syndrome 10/01/2017 - "The aim of the present study was to elucidate the effects of kisspeptin-10 (Kp-10) on ovarian hyperstimulation syndrome (OHSS) and its related mechanism in OHSS rat models, human umbilical vein endothelial cells (HUVECs) and human luteinized granulosa cells. "
5.	Shock 12/01/2019 - "This study investigated whether kisspeptin-10 (KP-10) prevents diabetic rhesus monkeys from insulin-induced hypoglycemic shock. "

Related Drugs and Biologics

1.	Kisspeptins
2.	Insulin (Novolin)
3.	Hypoglycemic Agents (Hypoglycemics)
4.	Peptides (Polypeptides)
5.	Vasoconstrictor Agents
6.	Testosterone (Sustanon)
7.	Hormones (Hormone)
8.	Kisspeptin-1 Receptors
9.	ErbB Receptors (EGF Receptor)
10.	Chemokine CXCL12

Related Therapies and Procedures

1.	Aftercare (After-Treatment)