JTH 601

JTH-601 is the hemifumarate salt; structure in first source

Also Known As:

JTH-601; N-(3-hydroxy-6-methoxy-2,4,5-trimethylbenzyl)-N-methyl-2-(4-hydroxy-2-isopropyl-5-methylphenoxy)ethylamine hemifumarate; Phenol, 3-(((2-(4-hydroxy-5-methyl-2-(1-methylethyl)phenoxy)ethyl)methylamino)methyl)-4-methoxy-2,5,6-trimethyl-, (2E)-2-butenedioate (1:2) (salt)

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Cresols: 9
        JTH 601: 4

Experts

1.	Aisaka, K: 1 article (04/2000)
2.	Kanada, A: 1 article (04/2000)
3.	Okaya, Y: 1 article (04/2000)
4.	Suzuki, Y: 1 article (04/2000)

Related Diseases

1.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 06/25/1999 - "JTH-601 is therefore expected to be effective in the treatment of urinary outlet obstruction in benign prostatic hypertrophy." 04/07/2000 - "JTH-601 is expected to be an effective alpha(1)-adrenoceptor antagonist for the treatment of urinary outlet obstruction by benign prostatic hypertrophy with a minimum effect on the cardiovascular system." 07/01/1999 - "This finding may be important in characterizing the therapeutic effect of JTH-601 for bladder outlet obstruction in patients with benign prostatic hyperplasia." 01/01/1998 - "New types of alpha1-adrenoceptor antagonists (tamsulosin, KMD-3213 and JTH-601) are currently receiving a great deal of attention, especially in terms of developing effective therapeutic agents to treat bladder outlet obstruction with less side effects, such as postural hypotension, in patients with benign prostatic hyperplasia (BPH). "
2.	Orthostatic Hypotension (Postural Hypotension) 06/25/1999 - "In conscious rabbits, administered JTH-601 (0.01-1 mg/kg, i.v.) had a tendency to augment orthostatic hypotension, but dose dependency was not evident. " 01/01/1998 - "New types of alpha1-adrenoceptor antagonists (tamsulosin, KMD-3213 and JTH-601) are currently receiving a great deal of attention, especially in terms of developing effective therapeutic agents to treat bladder outlet obstruction with less side effects, such as postural hypotension, in patients with benign prostatic hyperplasia (BPH). "
3.	Urinary Bladder Neck Obstruction (Bladder Neck Obstruction) 07/01/1999 - "This finding may be important in characterizing the therapeutic effect of JTH-601 for bladder outlet obstruction in patients with benign prostatic hyperplasia." 01/01/1998 - "New types of alpha1-adrenoceptor antagonists (tamsulosin, KMD-3213 and JTH-601) are currently receiving a great deal of attention, especially in terms of developing effective therapeutic agents to treat bladder outlet obstruction with less side effects, such as postural hypotension, in patients with benign prostatic hyperplasia (BPH). "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Tamsulosin (Flomax)
3.	silodosin