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epoxyazadiradione

limonoid from neem tree Azadirachta indica; RN given for (5alpha,7alpha,13alpha,14beta,15beta,17alpha)-isomer; structure in first source

Networked: 9 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Limonins: 143
        epoxyazadiradione: 9

Experts

1.	Nair, Mangalam S: 2 articles (10/2020 - 12/2017)
2.	Haldar, Saikat: 2 articles (01/2018 - 07/2012)
3.	Thulasiram, Hirekodathakallu V: 2 articles (01/2018 - 07/2012)
4.	B Sasidhar, Somappa: 1 article (06/2021)
5.	Lakshmi, Sreerenjini: 1 article (06/2021)
6.	Priya, Sulochana: 1 article (06/2021)
7.	Renjitha, Jalaja: 1 article (06/2021)
8.	Aggarwal, Sadhna: 1 article (10/2020)
9.	Aggarwal, Sushil Kumar: 1 article (10/2020)
10.	Awasthee, Nikee: 1 article (10/2020)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "Our findings demonstrate that epoxyazadiradione inhibits PI3K/Akt-dependent mitochondrial depolarisation, induces apoptosis and attenuates cell migration, angiogenesis and breast tumor growth suggesting that this compound may act as a potent therapeutic agent for the management of breast cancer." 01/01/2018 - "Our in vivo data revealed that epoxyazadiradione suppresses breast tumor growth and angiogenesis in orthotopic NOD/SCID mice model. " 01/01/2018 - "We have also analyzed the effect of epoxyazadiradione on breast tumor growth using in vivo mice model. " 01/01/2018 - "The molecular mechanism was examined in two different type of breast cancer cells in response to epoxyazadiradione. " 01/01/2018 - "Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway."
2.	Malaria 07/13/2012 - "In contrast, epoxyazadiradione inhibited both huMIF and plasmodial MIF, thus bearing an immense therapeutic potential against proinflammatory reactions induced by MIF of both malaria parasites and human." 07/13/2012 - "Epoxyazadiradione inhibited the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K(i), 2.11-5.23 μm). " 07/07/2017 - "Epoxyazadiradione (1), a major compound derived from Neem oil, showed modest anti-plasmodial activity against CQ-resistant and CQ-sensitive strains of the most virulent human malaria parasite P. falciparum. "
3.	Neoplasms (Cancer) 09/27/2023 - "Investigation of the anti-cancer potential of epoxyazadiradione in neuroblastoma: experimental assays and molecular analysis." 01/01/2018 - "In this study, we for the first time investigated that out of 10 major limonoids isolated from Azadirachta indica, epoxyazadiradione exhibits most potent anti-cancer activity in both TNBC and ER+ breast cancer cells. "
4.	Triple Negative Breast Neoplasms 06/01/2021 - "Epoxyazadiradione induced apoptosis/anoikis in triple-negative breast cancer cells, MDA-MB-231, by modulating diverse cellular effects."
5.	Carcinogenesis 08/17/2023 - "Epoxyazadiradione inhibits pro-inflammatory and kinase-driven signaling pathways to block tumorigenesis. "

Related Drugs and Biologics

1.	Limonins
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	Artesunate
5.	neem oil