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dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa
inhibits thrombin generation
Also Known As:
DEGR-Xa; dansyl-Glu-gly-Arg CMK-treated factor Xa
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Blood Proteins: 12459
Blood Coagulation Factors: 5376
Factor X: 649
Factor Xa: 1088
dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa: 7
Amino Acids: 30675
Amino Acid Chloromethyl Ketones
dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa: 7
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Peptide Hydrolases: 23957
Serine Proteases: 3726
Serine Endopeptidases: 11
Factor Xa: 1088
dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa: 7
Endopeptidases: 633
Serine Endopeptidases: 11
Factor Xa: 1088
dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa: 7
Biological Factors: 2472
Blood Coagulation Factors: 5376
Factor X: 649
Factor Xa: 1088
dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xa: 7
Related Diseases
1.
Vascular System Injuries
02/01/1997 - "
UTM did not prevent ET-induced pulmonary accumulation of leukocytes and pulmonary vascular injury in rats pretreated with DEGR-Xa.
"
09/01/1996 - "
rhs-TM did not prevent ET-induced pulmonary accumulation of leukocytes and pulmonary vascular injury in rats pretreated with DEGR-Xa.
"
02/01/1997 - "
LPS-induced pulmonary vascular injury was prevented by APC but not by active site-blocked factor Xa [dansyl glutamyl-glycyl-arginyl chloromethyl detone-treated activated factor X (DEGR-Xa)], a selective inhibitor of thrombin generation, or inactivated APC [diisopropyl fluorophosphate-treated APC (DIP-APC)].
"
01/15/1996 - "
Heparin plus antithrombin III (ATIII) and active site-blocked factor Xa (DEGR-Xa), a selective inhibitor of thrombin generation, inhibited LPS-induced coagulopathy but did not prevent LPS-induced pulmonary vascular injury.
"
11/01/1995 - "
Neither heparin plus antithrombin III (AT III) nor dansyl Glu Gly Arg chloromethyl ketone-treated factor Xa (DEGR-Xa), a selective inhibitor of thrombin generation, prevented LPS-induced vascular injury.
"
2.
Sepsis (Septicemia)
07/15/1991 - "
In evaluating the role of coagulation in sepsis we used factor Xa blocked in the active center with [5-(dimethylamino)1-naphthalenesulfonyl]-glutamylglycylarginyl+ ++ chloromethyl ketone (DEGR-Xa).
"
3.
Reperfusion Injury
05/01/1997 - "
We investigated the role of anticoagulant in the ischemia/reperfusion injury of the liver, using activated protein C (APC), active human urinary thrombomodulin (UTM), and factor Xa blocked at the active site (DEGR-Xa).
"
Related Drugs and Biologics
1.
Factor Xa (Coagulation Factor Xa)
2.
Thrombin
3.
Heparin (Liquaemin)
4.
Antithrombin III
5.
Thrombomodulin
6.
Protein C
7.
Ketones
8.
Anticoagulants
9.
1- myristoyl- 2- (12- ((5- dimethylamino- 1- naphthalenesulfonyl)amino)dodecanoyl)- sn- glycero- 3- phosphocholine
10.
dansylglutamyl-glycyl-arginine chloromethyl ketone