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TDO inhibitor LM10

a tryptophan 2,3-dioxygenase inhibitor; structure given in first source

Also Known As:

6-fluoro-3-(2-(3-pyridyl)vinyl)-1H-indole; 680C91; LM10; TDO inhibitor LM-10

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - TDO inhibitor LM10: 9

Experts

1.	Aldape, Kenneth: 1 article (10/2022)
2.	Asanigari, Saleembhasha: 1 article (10/2022)
3.	Chung, Hye-Jung: 1 article (10/2022)
4.	Dazelle, Karen: 1 article (10/2022)
5.	Hannenhalli, Sridhar: 1 article (10/2022)
6.	Mehani, Bharati: 1 article (10/2022)
7.	Singh, Arashdeep: 1 article (10/2022)
8.	Boos, Drake: 1 article (10/2021)
9.	Chuang, Tsai-Der: 1 article (10/2021)
10.	Khorram, Omid: 1 article (10/2021)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 11/03/2017 - "To study CRC metastasis, we generated a highly invasive, metastatic cell line MC38-LM10 (LM10) by passaging mouse CRC MC38 cells ten times, using a splenic injection model of liver metastasis. " 11/03/2017 - "Upregulation of β4-integrin in highly aggressive LM10 cells is associated with increased migration, invasion, and liver metastases. " 11/03/2017 - "This signature shows strong upregulation of β4-integrin in LM10 cells and corresponding metastases. " 11/03/2017 - "Affymetrix microarray analyses of LM10 and MC38 cell lines and their corresponding liver metastases generated a gene signature for CRC metastasis. "
2.	Neoplasms (Cancer) 10/01/2022 - "We confirmed and extended these findings by applying a signature matrix derived from single-cell RNA-sequencing data derived from 19 glioma tumor samples to the bulk profiling data, validating findings from the LM22/LM10 results. " 10/01/2019 - "Existing TDO inhibitors other than glucose include allopurinol, nicotinamide and recently developed potent inhibitors such as LM10 used in cancer therapy. "
3.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 11/01/2023 - "Furthermore, 680C91 suppressed production of proinflammatory cytokines and STAT signaling in an animal model of inflammatory bowel disease. "
4.	Virus Diseases (Viral Diseases) 01/01/2020 - "Results showed that in vivo TDO inhibition by LM10, a derivative of 3-(2-(pyridyl) ethenyl) indole, resulted in a decrease of anti- MHV Ab titers induced by the virus infection. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2021 - "Treatment with LM10, a TDO2 inhibitor, also repressed the proliferation, migration and invasion of ovarian cancer cells. "

Related Drugs and Biologics

1.	TDO inhibitor LM10
2.	Collagen Type I (Type I Collagen)
3.	Dextran Sulfate
4.	Cytokines
5.	RNA (Ribonucleic Acid)
6.	Niacinamide (Nicotinamide)
7.	Glucose (Dextrose)
8.	Dopamine (Intropin)
9.	Allopurinol (Remid)
10.	indole

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy