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methotrexate-alpha-phenylalanine
Also Known As:
MTX-Phe
Networked:
5
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Pteridines: 147
Pterins: 160
Aminopterin: 248
Methotrexate: 24010
methotrexate-alpha-phenylalanine: 5
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Essential Amino Acids: 1152
Phenylalanine: 4090
methotrexate-alpha-phenylalanine: 5
Cyclic Amino Acids: 3
Aromatic Amino Acids: 467
Phenylalanine: 4090
methotrexate-alpha-phenylalanine: 5
Related Diseases
1.
Neoplasms (Cancer)
02/01/1996 - "
These results suggest that MTX-Phe combined with 4E3-CPA conjugate is a promising model for a more selective and localised anti-cancer chemotherapy based on the ADEPT concept.
"
02/01/1995 - "
When the lung tumor cells were treated with CPA conjugated to KS1/4 (a mAb targeted to these cells) and excess conjugate removed by extensive washing, the ID50 for MTX-Phe improved from 2.2 x 10(-6) M (no enzyme present) to 6.3 x 10(-8) M; the latter value was comparable to that of the parent drug MTX (4.5 x 10(-8) M).
"
10/01/1994 - "
These results suggest that MTX-Phe is a potent prodrug and could be used in a drug targeting model combining monoclonal antibodies coupled with CP-A for a more specific approach in cancer therapy.
"
2.
Adenocarcinoma of Lung
01/01/1997 - "
When administered in vitro to UCLA-P3 human lung adenocarcinoma cells (ca. 5 x 10(4) antibody binding sites/cell) that had been pre-treated with the conjugate (whose antibody KS1/4 is targeted to these cells), and excess conjugate removed by extensive washing, MTX-Phe (ID50 = 6.3 x 10(-8) M) approached the toxicity of MTX (ID50 = 4.5 x 10(-8) M).
"
02/01/1995 - "
The amount of CPA required to make MTX-Phe equitoxic with MTX, when tested against UCLA-P3 human lung adenocarcinoma cells in vitro, was more than 10-fold lower than that required to achieve the same result with MTX-alpha-alanine.
"
3.
Teratocarcinoma
10/01/1994 - "
In vitro assays on a human ovarian teratocarcinoma cell line (CRL-1572), showed that MTX-Phe was non toxic, but when combined with 1 mU of CP-A, MTX-Phe cytotoxicity was enhanced considerably showing only two times less pharmacological activity than MTX.
"
4.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/20/1999 - "
In addition, endogenously activated CPA95 could effectively sensitize cells to MTX-Phe in culture, decreasing the IC50 of MTX-Phe from 25- to 250-fold in squamous cell carcinoma cells expressing active CPA as compared with the parental lines.
"
Related Drugs and Biologics
1.
Enzymes
2.
Prodrugs
3.
Monoclonal Antibodies
4.
Alanine (L-Alanine)
Related Therapies and Procedures
1.
Therapeutics
2.
Drug Therapy (Chemotherapy)