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N- (S- acetylmercaptoacetyl)- 4- isothiocyanate- phenylalanyl- glycyl- glycine ethyl ester

peptide-based bifunctional chelating agent for (99m)Tc & (186)Re labeling of monoclonal antibodies; structure in first source

Also Known As:

MAIPGG

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - N-(S-acetylmercaptoacetyl)-4-isothiocyanate-phenylalanyl-glycyl-glycine ethyl ester: 1
Organic Chemicals: 133
- Isocyanates: 512
  - Isothiocyanates: 501
    - N-(S-acetylmercaptoacetyl)-4-isothiocyanate-phenylalanyl-glycyl-glycine ethyl ester: 1
- Sulfur Compounds: 278
  - Isothiocyanates: 501
    - N-(S-acetylmercaptoacetyl)-4-isothiocyanate-phenylalanyl-glycyl-glycine ethyl ester: 1

Related Diseases

1.	Neoplasms (Cancer) 02/01/1994 - "These preliminary results suggest that MAIPGG may be useful for the radiolabeling of a variety of monoclonal antibodies with 99mTc or 186Re, which then can be used for radioimmunodetection and radioimmunotherapy of cancer."
2.	Colonic Neoplasms (Colon Cancer) 02/01/1994 - "The biodistribution of 99mTc/186Re-MAIPGG-D612 conjugates was studied in nude mice bearing human colon cancer xenografts. " 02/01/1994 - "The authors have developed a new N3S-ligand, N-(S-acetylmercaptoacetyl) (p-NCS)phenylalanylglycylglycine ethyl ester (MAIPGG) for technetium-99m (99mTc) or rhenium-186 (186Re) labeling of monoclonal antibody D612 reactive with human colon cancer. "

Related Drugs and Biologics

1.	Esters
2.	Monoclonal Antibodies
3.	Rhenium-186

Related Therapies and Procedures

1.	Radioimmunotherapy