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Zymocel
betafectin is a soluble hydrolysis product of zymocel
Also Known As:
poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose polymer
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Macromolecular Substances: 97
Polymers: 13051
Biopolymers: 773
Glucans: 1624
Zymocel: 2
Carbohydrates: 22023
Polysaccharides: 15383
Glucans: 1624
Zymocel: 2
Experts
1.
Dranoff, G
: 1 article (01/2001)
2.
Miyakawa, K
: 1 article (01/2001)
3.
Miyata, E
: 1 article (01/2001)
4.
Takahashi, K
: 1 article (01/2001)
5.
Takeya, M
: 1 article (01/2001)
6.
Wynn, A A
: 1 article (01/2001)
Related Diseases
1.
Sarcoma 180
12/01/1996 - "
Zymocel also showed anti-tumour activity against sarcoma 180 in mice and also enhanced TNF synthesis and hydrogen peroxide production by macrophage-like cell line in-vitro, i.e.
"
2.
Necrosis
12/01/1996 - "
Administration of zymocel increased peritoneal exudate cell number and spleen weight, and enhanced: phagocytic activity, hydrogen peroxide production, and nitric oxide production of peritoneal exudate cells; the extravascular release of Evans blue (which might reflect vascular permeability); lipopolysaccharide-triggered synthesis of tumour necrosis factor (TNF); and recovery of white blood cell number in cyclophosphamide-induced leukopenia.
"
3.
Leukopenia
12/01/1996 - "
Administration of zymocel increased peritoneal exudate cell number and spleen weight, and enhanced: phagocytic activity, hydrogen peroxide production, and nitric oxide production of peritoneal exudate cells; the extravascular release of Evans blue (which might reflect vascular permeability); lipopolysaccharide-triggered synthesis of tumour necrosis factor (TNF); and recovery of white blood cell number in cyclophosphamide-induced leukopenia.
"
4.
Granuloma
01/01/2001 - "
The DNA nick-end-labeling method demonstrated increased numbers of apoptotic cells in and around hepatic granulomas of GM-CSF(-/-) mice from 8 days after zymocel injection, and electron microscopy detected apoptotic bodies.
"
01/01/2001 - "
To examine the role of granulocyte/macrophage colony-stimulating factor (GM-CSF) in inflammatory granuloma formation, we injected GM-CSF-deficient (GM-CSF(-/-)) mice and wild-type (GM-CSF(+/+)) mice intravenously with 2 mg of zymocel, and mice were killed at various intervals for examination.
"
01/01/2001 - "
Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation.
"
01/01/2001 - "
In GM-CSF(-/-) mice, we demonstrated a marked delay of zymocel-induced hepatic granuloma formation until 5 days after zymocel injection with a rapid reduction in numbers of granulomas at 10 days until their disappearance.
"
Related Drugs and Biologics
1.
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
2.
Nitric Oxide (Nitrogen Monoxide)
3.
Lipopolysaccharides
4.
Hydrogen Peroxide (Hydroperoxide)
5.
Evans Blue (Blue, Evans)
6.
Dihydrotachysterol (AT 10)
7.
Cyclophosphamide (Cytoxan)