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phenylalanyl-arginyl-arginine

a novel tripeptide exerting Zn2+-dependent, insulin-mimetic inhibitory action on myocardial proteolysis

Also Known As:

Phe-Arg-Arg

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - phenylalanyl-arginyl-arginine: 3

Experts

1.	Kim, Jinseong: 3 articles (10/2021 - 12/2020)
2.	Kim, Kwangmeyung: 3 articles (10/2021 - 12/2020)
3.	Moon, Yujeong: 3 articles (10/2021 - 12/2020)
4.	Shim, Man Kyu: 3 articles (10/2021 - 12/2020)
5.	Yang, Suah: 3 articles (10/2021 - 12/2020)
6.	Choi, Jiwoong: 2 articles (10/2021 - 01/2021)
7.	Kim, Jeongrae: 2 articles (10/2021 - 01/2021)
8.	Song, Sukyung: 1 article (10/2021)
9.	Kim, Han Young: 1 article (01/2021)
10.	Kim, In-San: 1 article (01/2021)

Related Diseases

1.

Neoplasms (Cancer)

10/01/2021 - "The cancer-specific PNPs were constructed by conjugating cathepsin B-specific cleavable peptide (Phe-Arg-Arg-Gly; FRRG) to DOX, resulting in FRRG-DOX that self-assembled into nanoparticles and the FRRG-DOX nanoparticles were further stabilized with the FDA-approved pharmaceutical excipient, Pluronic F68. "
01/01/2021 - "Herein, we constructed cancer-activated DOX prodrug by conjugating the cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly, FRRG) to a doxorubicin (DOX), resulting in FRRG-DOX that self-assembled into cancer-activated DOX prodrug nanoparticles (CAP-NPs). "
12/01/2020 - "Cancer-specific and pro-apoptotic drug-drug conjugate was prepared by conjugating the pro-apoptotic peptide drug (SMAC; Ala-Val-Pro-Ile-Ala-Gln, AVPIAQ) and cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly, FRRG) to a doxorubicin (DOX), resulting in SMAC-FRRG-DOX that allows self-assembled into nanoparticles. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Cathepsin B
3.	Doxorubicin (Adriamycin)
4.	Poloxamer (Poloxamer 407)
5.	Prodrugs
6.	Excipients (Suspending Agents)
7.	prolylisoleucine
8.	alanylglutamine