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LY 231617
structure given in first source; LY 231617 is the HCl salt; RN given refers to the parent compound
Also Known As:
2,6-bis(1,1-dimethylethyl)-4-(((1-ethyl)amino)methyl)phenol; LY 231617, hydrochloride salt; LY 231617, nitrate salt; LY-231617; LY231617
Networked:
13
relevant articles (
5
outcomes,
4
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Cresols: 9
Butylated Hydroxytoluene: 812
LY 231617: 13
Experts
1.
Bhardwaj, A
: 1 article (01/2000)
2.
Kirsch, J R
: 1 article (01/2000)
3.
Toung, T J
: 1 article (01/2000)
4.
Traystman, R J
: 1 article (01/2000)
5.
Wang, M
: 1 article (01/2000)
Related Diseases
1.
Ischemia
04/22/1996 - "
These results suggest that LY231617 can offer considerable protection against global ischemia-induced cell death in the hippocampus with resulting preservation of spatial memory abilities.
"
04/01/1997 - "
In addition, LY 231617 reduced the deficit in spatial memory as demonstrated by minimizing the ischemia-induced reduction in time spent in the quadrant of the former platform position during the probe trial.
"
01/01/2000 - "
LY231617 improves recovery of cerebral electrical function after complete transient global ischemia via mechanisms unrelated to cerebral circulatory effects.
"
05/01/1993 - "
LY231617 was either given orally 30 minutes before ischemia or intravenously beginning at 30 minutes after the onset of ischemia.
"
10/02/1995 - "
The antioxidant LY 231617 ameliorates functional and morphological sequelae induced by global ischemia in rats.
"
2.
Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
08/01/1996 - "
The efficacy of retrograde infusion with LY231617 in a rat middle cerebral artery occlusion model.
"
3.
Reperfusion Injury
03/01/1997 - "
RPCV with and without LY231617 during occlusion was effective for attenuating reperfusion injury.
"
4.
Transient Ischemic Attack
10/02/1995 - "
In this study the effect of LY 231617, an antioxidant, on spatial learning deficit and on neuronal damage following transient cerebral ischemia was evaluated.
"
5.
Brain Ischemia (Cerebral Ischemia)
01/01/2000 - "
We tested the hypothesis that administration of LY231617, before the insult, would improve recovery of cerebral electrical activity and metabolic function after transient global cerebral ischemia by improving cerebral blood flow (CBF) during the reperfusion period.
"
01/01/2000 - "
Antioxidant LY231617 enhances electrophysiologic recovery after global cerebral ischemia in dogs.
"
01/01/2000 - "
The potent antioxidant LY231617 (2,6-bis(1,1-dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol hydrochloride) is cytoprotective in models of focal and global cerebral ischemia.
"
04/01/1997 - "
Global cerebral ischemia was induced in male Wistar rats by four-vessel occlusion for 20 min. Ischemic rats were then treated with the noncompetitive non-NMDA receptor antagonist GYKI 52466 (30 mg/kg), the radical scavenger LY 231617 (20 mg/kg), the inhibitor of protein kinase C staurosporine (0.1 mg/kg), or solvent.
"
Related Drugs and Biologics
1.
Antioxidants
2.
Hydrogen Peroxide (Hydroperoxide)
3.
Reactive Oxygen Species (Oxygen Radicals)
4.
NF-kappa B (NF-kB)
5.
Phenol (Carbolic Acid)
6.
Clusterin
7.
Staurosporine
8.
N-Methyl-D-Aspartate Receptors (NMDA Receptors)
9.
Solvents
10.
RNA (Ribonucleic Acid)