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2-(nitrooxy)ethyl apovincaminate
structure given in first source
Also Known As:
NOEtApoV; VA 045; VA-045; eburnamenine-14 carboxylic acid (2-nitroxyethyl)ester; Eburnamenine-14-carboxylic acid, 2-(nitrooxy)ethyl ester, (3alpha,16alpha)-
Networked:
11
relevant articles (
3
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Vinca Alkaloids: 463
2-(nitrooxy)ethyl apovincaminate: 11
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Vinca Alkaloids: 463
2-(nitrooxy)ethyl apovincaminate: 11
Indolizines: 3
Indolizidines: 2
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Vinca Alkaloids: 463
2-(nitrooxy)ethyl apovincaminate: 11
Related Diseases
1.
Closed Head Injuries
01/01/1993 - "
Effect of VA-045 on a closed head injury model in rats.
"
06/01/1997 - "
Effects of VA-045, a novel apovincaminic acid derivative, on behavioral outcome following closed head injury (CHI) were examined in aged (21-28 months) rats.
"
06/01/1997 - "
Effect of VA-045, a novel apovincaminic acid derivative, on closed head injury-induced neurological dysfunction in aged rats.
"
01/01/1997 - "
1. We examined the alterations in cerebral free Mg2+ concentration in closed head injury (CHI) in rats and the effects of VA-045, a novel apovincaminic acid derivative, on them with in vivo 31P-NMR.
"
01/01/1997 - "
Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats.
"
2.
Hypoxia (Hypoxemia)
10/01/1994 - "
VA-045 and thyrotropin releasing hormone (TRH) showed a significant protective effect on normobaric hypoxia.
"
10/01/1994 - "
Beneficial effects of VA-045 for treating cerebral hypoxia, anoxia and ischemia will be discussed.
"
01/01/1996 - "
VA-045, a novel apovincamic acid derivative attenuates neuronal injury induced by hypoxia or by excitatory amino acids in cultures of rat cortices.
"
10/01/1994 - "
The cerebral protective effects of VA-045, a novel apovincaminic acid derivative, were investigated in mice under conditions of normobaric hypoxia, histotoxic anoxia by potassium cyanide (KCN), and complete ischemia.
"
01/01/1996 - "
Effects of VA-045, a novel apovincaminic acid derivative, on neuronal damage induced by hypoxia or by excitatory amino acids (glutamate (Glu), N-methyl-D-aspartate and kainate) were examined in cultures of the rat cortices.
"
3.
Wounds and Injuries (Trauma)
09/01/1997 - "
5. VA-045 administered 30 min post-trauma in TAA mice dramatically attenuated the prolonged latencies for finding and drinking in both retention test and retest, indicating that VA-045 significantly improved the learning and retention deficits observed in TAA mice.
"
09/01/1997 - "
4. VA-045 administered 30 min post-trauma in TRA mice dramatically shortened the prolonged latencies for finding and drinking in both retention test and retest, indicating that VA-045 significantly improved the retention deficit observed in TRA mice.
"
09/01/1997 - "
6. Administration of VA-045 30 min pre-trauma in normal mice markedly attenuated the delay of latencies for finding and drinking after trauma in both retention test and retest, which shows that VA-045 significantly prevented learning and retention deficits after TBI.
"
4.
Ischemia
10/01/1994 - "
VA-045 and TRH showed a positive effect on complete ischemia, and the duration of the protective effect of VA-045 was longer than that of TRH.
"
10/01/1994 - "
Beneficial effects of VA-045 for treating cerebral hypoxia, anoxia and ischemia will be discussed.
"
10/01/1994 - "
The cerebral protective effects of VA-045, a novel apovincaminic acid derivative, were investigated in mice under conditions of normobaric hypoxia, histotoxic anoxia by potassium cyanide (KCN), and complete ischemia.
"
5.
Stroke (Strokes)
01/01/1993 - "
These results indicate that VA-045 selectively dilates canine cerebral artery, and that it may be a useful agent for the treatment of cerebrovascular diseases such as stroke.
"
Related Drugs and Biologics
1.
apovincaminic acid
2.
Thyrotropin-Releasing Hormone (Protirelin)
3.
Potassium Cyanide
4.
vinpocetine
5.
Excitatory Amino Acids
6.
Glutamic Acid (Glutamate)
7.
N-Methylaspartate (NMDA)
8.
Magnesium
9.
Kainic Acid (Kainate)
10.
Clonidine (ST 155)
Related Therapies and Procedures
1.
Intravenous Injections