Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats.

Abstract

1. We examined the alterations in cerebral free Mg2+ concentration in closed head injury (CHI) in rats and the effects of VA-045, a novel apovincaminic acid derivative, on them with in vivo 31P-NMR. 2. Free Mg2+ decreased by about 30% within 20 min after head impact and, afterward, it gradually decreased further to reach about 60% of the control level after 3 hr. VA-045 inhibited the decrease. 3. In nonimpacted rats, VA-045 did not alter the free Mg2+ level. 4. The decrease in cerebral free Mg2+ following CHI may be a critical factor in the development of irreversible tissue injury, and VA-045 may prevent it.

• Authors: M Suzuki, M Nishina, M Endo, K Matsushita, M Tetsuka, K Shima, S Okuyama
• Journal: General pharmacology (Gen Pharmacol) Vol. 28 Issue 1 Pg. 119-21 (Jan 1997) ISSN: 0306-3623 [Print] England
• PMID: 9112087 (Publication Type: Journal Article)

Chemical References

• Magnesium

Topics

• Animals
• Brain Chemistry
• Head Injuries, Closed (metabolism)
• Hydrogen-Ion Concentration
• Magnesium (analysis)
• Magnetic Resonance Spectroscopy
• Male
• Rats
• Rats, Wistar