Y 29794

structure given in first source; non-peptide prolyl endopeptidase inhibitor

Also Known As:

2-(8-dimethylaminooctylthio)-6-isopropyl-3-pyridyl-2-thienyl ketone citrate; Y-29794; Y29794; Methanone, (2-((8-(dimethylamino)octyl)thio)-6-(1-methylethyl)-3-pyridinyl)-2-thienyl-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Y 29794: 1
- Sulfur Compounds: 278
  - Thiophenes: 257
    - Y 29794: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - Y 29794: 1

Experts

1.	Calhoun, Sarah: 1 article (11/2020)
2.	Duan, Lei: 1 article (11/2020)
3.	Levenson, Victor V: 1 article (11/2020)
4.	Maki, Carl G: 1 article (11/2020)
5.	Perez, Ricardo E: 1 article (11/2020)
6.	Shim, Daeun: 1 article (11/2020)

Related Diseases

1.	Triple Negative Breast Neoplasms 11/01/2020 - "Using cell line models of aggressive triple-negative breast cancer (TNBC), we show here that Y-29794 inhibited proliferation and induced death in multiple TNBC cell lines. " 11/01/2020 - "Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer."
2.	Neoplasms (Cancer) 11/01/2020 - "Induction of cell death in culture and inhibition of xenograft tumor growth support the potential utility of Y-29794 or its derivatives as a treatment option for TNBC tumors." 11/01/2020 - "Importantly, Y-29794 inhibited tumor growth when tested in xenograft models of TNBC in mice. " 11/01/2020 - "These results suggest that Y-29794 elicits its cancer cell killing effect by targeting other mechanisms in addition to PREP. " 11/01/2020 - "However, there are no reports on Y-29794 effects on cancer cell and tumor proliferation. " 11/01/2020 - "Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer."

Related Drugs and Biologics

1.	Prolyl Oligopeptidases