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FR 110302
structure given in first source; a potent 5-lipoxygenase inhibitor
Also Known As:
2,2-dibutyl-5-(2-quinolylmethoxy)-1,2,3,4-tetrahydro-1-naphthol; FR-110302; FR110302; 1-Naphthalenol, 2,2-dibutyl-1,2,3,4-tetrahydro-5-(2-quinolinylmethoxy)-
Networked:
3
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Naphthols: 64
FR 110302: 3
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Naphthols: 64
FR 110302: 3
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
FR 110302: 3
Related Diseases
1.
Asthma (Bronchial Asthma)
07/01/1992 - "
FR110302 (10 mg/kg b.i.d.p.o.) significantly suppressed both of these indicators of asthma.
"
07/01/1997 - "
Many of these medications appear to be effective in the treatment of asthma (BAYX-1005; MK-0591; MK-886; AA-681; A-64077; ZD-2138; U-60257; FR-110302; BI-6239; A-78773; ABT-761; L-746530; L-699333; ZM-230487).
"
2.
Respiratory Hypersensitivity
03/01/1993 - "
These results suggest that FR110302 may be a useful drug for attenuating airway hyperresponsiveness in asthmatic patients.
"
03/01/1993 - "
In the present study we examined the inhibitory effect of a potent 5-lipoxygenase inhibitor, FR110302, on airway hyperresponsiveness induced by ozone exposure in guinea pigs and dogs.
"
03/01/1993 - "
A 5-lipoxygenase inhibitor, FR110302, inhibits ozone-induced airway hyperresponsiveness in guinea pigs and dogs.
"
07/01/1992 - "
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
"
07/01/1992 - "
To study the role of chemical mediators in airway hyperresponsiveness and simultaneous eosinophilia, we examined effects of a potent 5-lipoxygenase inhibitor FR110302 and those of prednisolone, indomethacin, platelet-activating factor (PAF) antagonist (RP-59227) and leukotriene C4 (LTC4) antagonist (ONO-1078) on airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles.
"
3.
Eosinophilia
07/01/1992 - "
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
"
07/01/1992 - "
To study the role of chemical mediators in airway hyperresponsiveness and simultaneous eosinophilia, we examined effects of a potent 5-lipoxygenase inhibitor FR110302 and those of prednisolone, indomethacin, platelet-activating factor (PAF) antagonist (RP-59227) and leukotriene C4 (LTC4) antagonist (ONO-1078) on airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles.
"
Related Drugs and Biologics
1.
L 746530
2.
atreleuton
3.
ZM 230487
4.
L 699333
5.
A 78773
6.
MK 0591
7.
ICI D2138
8.
zileuton (Zyflo)
9.
MK-886
10.
piriprost