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poly (arginyl-glycyl-aspartic acid)
RN given refers to parent cpd
Also Known As:
poly (arginyl-glycyl-aspartic acid) mesylate; poly(Arg-Gly-Asp); poly(RGD)
Networked:
12
relevant articles (
4
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
poly (arginyl-glycyl-aspartic acid): 12
Experts
1.
Bigda, Jacek
: 1 article (01/2003)
2.
DobrzaĆska-Paprocka, Zuzanna
: 1 article (01/2003)
3.
Okrój, Marcin
: 1 article (01/2003)
4.
Rolka, Krzysztof
: 1 article (01/2003)
Related Diseases
1.
Melanoma (Melanoma, Malignant)
08/01/1989 - "
In our previous study, the lung metastatic formation of tumour cells was dramatically reduced by intravenous co-injection of anti-cell adhesive poly (Arg-Gly-Asp) with B16-BL6 melanoma cells.
"
01/01/2003 - "
The anti-tumour effect of poly RGD observed in the Ab Bomirski melanoma model is probably due to an anti-adhesive mechanism.
"
09/01/1991 - "
Molecular properties of poly(RGD) and its binding capacities to metastatic melanoma cells.
"
01/01/2003 - "
The most active peptide (poly RGD) was also tested in vivo to assess its modulatory activity on melanoma growth.
"
06/01/1990 - "
Single intratumoral administration of poly(RGD) on day 0, 1 or 7 after tumor implantation achieved a significant reduction of B16-BL6 melanoma colonization in the lungs, but did not affect the size of the primary tumor at the time of amputation.
"
2.
Neoplasms (Cancer)
04/01/1999 - "
Poly (RGD) showed no cytotoxicity against host and tumor cells.
"
06/01/1990 - "
Poly(RGD) significantly inhibited the formation of tumor neovascularization when co-injected with the tumor cells or separately injected intratumorally or intravenously on day 1 or 3 after tumor inoculation.
"
07/15/1989 - "
In a spontaneous metastasis model, multiple i.v. administrations of poly(Arg-Gly-Asp) after tumor inoculation caused the significant reduction of metastatic colonies in the lung but did not affect the growth (size) of primary tumor.
"
11/01/1997 - "
Poly(RGD) inhibited experimental lung and liver metastasis effectively when coinjected i.v. with various types of tumors.
"
07/01/1995 - "
Poly (RGD) effectively inhibited the experimental lung and liver metastasis when coinjected i.v. with different types of tumors.
"
3.
Neoplasm Metastasis (Metastasis)
11/01/1989 - "
The results indicate that the poly(RGD)-mediated inhibition of tumour metastasis may be due to the interference of the adhesive interaction of tumour cells with a specific site in the target organs.
"
07/15/1989 - "
In a spontaneous metastasis model, multiple i.v. administrations of poly(Arg-Gly-Asp) after tumor inoculation caused the significant reduction of metastatic colonies in the lung but did not affect the growth (size) of primary tumor.
"
11/01/1997 - "
Poly(RGD) inhibited experimental lung and liver metastasis effectively when coinjected i.v. with various types of tumors.
"
07/01/1995 - "
Poly (RGD) effectively inhibited the experimental lung and liver metastasis when coinjected i.v. with different types of tumors.
"
01/01/1994 - "
Poly(RGD) effectively inhibited the experimental lung and liver metastasis when coinjected i.v. with different types of tumors.
"
Related Drugs and Biologics
1.
Peptides (Polypeptides)
2.
arginyl-glycyl-aspartic acid
3.
Fibronectins (Fibronectin)
4.
Integrins
5.
Cell Adhesion Molecules
6.
2-Chloroadenosine (2 Chloroadenosine)
7.
Laminin (Merosin)
8.
Heparin (Liquaemin)
9.
Carrageenan
10.
Amino Acids
Related Therapies and Procedures
1.
Surgical Amputation (Amputations)