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2',3'- didehydro- 2',3'- dideoxy- 5- chlorocytidine

structure given in first source

Also Known As:

D4CC

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Cytidine: 535
        Deoxycytidine: 307
        2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Cytidine: 535
      - Deoxycytidine: 307
        2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine: 2
  - Deoxyribonucleosides: 34
    - Deoxycytidine: 307
      - 2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine: 2

Experts

1.	Demmy, Todd: 1 article (07/2021)
2.	Dexter, Elisabeth: 1 article (07/2021)
3.	Farrugia, Mark: 1 article (07/2021)
4.	Fung-Kee-Fung, Simon: 1 article (07/2021)
5.	Gomez-Suescun, Jorge: 1 article (07/2021)
6.	Hennon, Mark: 1 article (07/2021)
7.	Ma, Sung Jun: 1 article (07/2021)
8.	Malhotra, Harish: 1 article (07/2021)
9.	Nwogu, Chukwumere: 1 article (07/2021)
10.	Picone, Anthony: 1 article (07/2021)

Related Diseases

1.	Neoplasms (Cancer) 07/10/2021 - "Within the matched cohort, dosimetric study found exceeding a D4cc of 18 Gy to either the proximal bronchus (HR = 3.9, p = 0.007) or trachea (HR = 4.0, p = 0.02) was correlated with worse non-cancer associated survival. " 07/10/2021 - "In patients undergoing five fraction SBRT, UCLT location was associated with worse non-cancer associated survival and OS, which could be secondary to excessive D4cc dose to the proximal airways."
2.	Simian Acquired Immunodeficiency Syndrome 11/15/1989 - "2',3'-Didehydro-2',3'-dideoxy-5-chlorocytidine (D4CC) is, in contrast with 2',3'-dideoxy-5-chlorocytidine (ddClCyd) and 2',3'-didehydro-2',3'-dideoxy-5-chlorouridine (D4CU), a potent and selective inhibitor of the replication of human immunodeficiency virus (HIV) types 1 and 2, simian immunodeficiency virus (SIV) and simian AIDS related virus (SRV). "

Related Drugs and Biologics

1.	2',3'- didehydro- 2',3'- dideoxy- 5- chlorocytidine