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phenyl- (2- difluoroethyl)- 4- aminopropylamidinohydrazone (DFPA)
structure given in first source
Also Known As:
DFPA
; difluorophenylethyl(4-aminopropylamidinohydrazone)
Networked:
3
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Polyamines: 3918
Diamines: 518
phenyl-(2-difluoroethyl)-4-aminopropylamidinohydrazone: 3
Hydrazines: 379
Hydrazones: 500
phenyl-(2-difluoroethyl)-4-aminopropylamidinohydrazone: 3
Related Diseases
1.
Thrombosis (Thrombus)
08/15/1989 - "
Finally, due to its cross-reactivity with dFPA, assays using this antibody should also be valuable in the canine experimental thrombosis model studies.
"
2.
Neoplasms (Cancer)
01/01/1991 - "
[18F]DFPA proved of value to image and circumscribe intracerebral tumors in awake rats, and studies are continuing to facilitate its clinical application in brain tumor patients.
"
01/01/1991 - "
Male Fischer 344 rats were intracerebrally implanted with Walker 256 carcinosarcoma tumor cells (1 x 10(6) in 5 microliters tissue culture media) and 7 days later were infused with [18F]DFPA (500-1000 mCi/mmol) i.v. for 5 min. Rats were killed after 20 min. Brains were removed and either prepared for autoradiography, or brain and tumor were separated and their radioactivity quantified by gamma spectroscopy.
"
3.
Brain Neoplasms (Brain Tumor)
01/01/1991 - "
Positron emitting dl-erythro-9,10[18F]difluoropalmitate, [18F]DFPA, was synthesized for the in vivo imaging of brain tumors in rats.
"
01/01/1991 - "
[18F]DFPA proved of value to image and circumscribe intracerebral tumors in awake rats, and studies are continuing to facilitate its clinical application in brain tumor patients.
"
4.
Leukemia
03/01/1988 - "
Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells.
"
5.
Carcinosarcoma
01/01/1991 - "
Male Fischer 344 rats were intracerebrally implanted with Walker 256 carcinosarcoma tumor cells (1 x 10(6) in 5 microliters tissue culture media) and 7 days later were infused with [18F]DFPA (500-1000 mCi/mmol) i.v. for 5 min. Rats were killed after 20 min. Brains were removed and either prepared for autoradiography, or brain and tumor were separated and their radioactivity quantified by gamma spectroscopy.
"
Related Drugs and Biologics
1.
S-Adenosylmethionine (Ademetionine)
2.
Ornithine
3.
Culture Media
4.
Carboxy-Lyases