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adult T cell leukemia-derived factor
MW 14 kDa
Also Known As:
3B6-IL-1; ADF autocrine growth factor; ATL-derived factor; ATL-derived factor (ADF); IL-2 receptor inducing factor; IL-2RIF; Tac p55-inducing factor; adult T-cell derived factor
Networked:
23
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Intercellular Signaling Peptides and Proteins: 29768
Cytokines: 164289
adult T cell leukemia-derived factor: 23
Neoplasm Proteins: 2
adult T cell leukemia-derived factor: 23
Peptides: 82426
Intercellular Signaling Peptides and Proteins: 29768
Cytokines: 164289
adult T cell leukemia-derived factor: 23
Biological Factors: 2472
Intercellular Signaling Peptides and Proteins: 29768
Cytokines: 164289
adult T cell leukemia-derived factor: 23
Related Diseases
1.
Reperfusion Injury
01/01/1994 - "
Effect of recombinant human adult T cell leukemia-derived factor on rat lung reperfusion injury.
"
08/01/1994 - "
Protective effect of adult T cell leukemia-derived factor on reperfusion injury in multivisceral transplantation.
"
07/01/1998 - "
To evaluate the protective effects of recombinant adult T-cell leukemia- derived factor (ADF)-human thioredoxin against ischemia-reperfusion injury in the rat retina.
"
07/01/1998 - "
Protective effect of adult T-cell leukemia-derived factor on retinal ischemia-reperfusion injury in the rat.
"
11/01/1994 - "
Inhibition of reperfusion injury by human thioredoxin (adult T-cell leukemia-derived factor) in canine lung transplantation.
"
2.
Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
04/15/1988 - "
Many human T cell lymphotropic virus-I (HTLV-I) transformed T cells from adult T cell leukemia (ATL) patients continuously produce a humoral factor called ATL-derived factor (ADF) which induces IL-2R/Tac expression on T and NK cells.
"
08/01/1994 - "
The adult T cell leukemia (ATL)-derived factor (ADF) was first described as an interleukin 2 receptor alpha chain (IL-2R alpha) inducing factor which is produced by an HTLV-I infected cell line.
"
03/01/1991 - "
A human T cell leukemia virus-I infected T cell line, ATL-2, produces an interleukin-2 receptor inducing factor, adult T cell leukemia (ATL)-derived factor (ADF).
"
04/01/1997 - "
In this study, we analyzed the effect of L-cystine and GSH depletion on lymphocyte survival and investigated the regulatory roles of adult T cell leukemia (ATL)-derived factor (ADF)/human thioredoxin (hTRX) in relation to these low m.w.
"
01/01/1999 - "
Human thioredoxin (hTRX)/adult T-cell leukemia (ATL)-derived factor (ADF) was originally reported as an interleukin-2 (IL-2) receptor-alpha-inducing factor produced by human T-cell lymphotropic virus-1-positive (HTLV-1+) cell lines.
"
3.
Neoplasms (Cancer)
05/01/1993 - "
We identified ATL-derived factor (ADF) in the cytoplasm of the secondary neoplasms of the ATL patients by means of indirect immunofluoroscopy and immunohistochemical techniques utilizing anti-ADF antibody.
"
10/01/1989 - "
We identified ATL-derived factor (ADF) in the cytoplasm of the secondary neoplasms of the ATL patients by means of indirect immunofluoroscopy and immunohistochemical techniques utilizing anti-ADF antibody.
"
02/01/1996 - "
Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines.
"
08/02/1994 - "
The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors.
"
4.
T-Cell Leukemia (Leukemia, T Cell)
04/01/1997 - "
We have examined the expression of an ATL-derived factor (ADF)/thioredoxin in relation to resistance to adriamycin (ADM) in various T-cell leukemia cell lines including ATL cell lines.
"
05/01/1994 - "
In mammalian cells, thioredoxin functions as an endogenous glucocorticoid receptor activating factor and as an adult T-cell leukemia-derived factor (ADF) that stimulates expression of interleukin-2 receptor in human T-cell leukemia virus (HTLV)-I transformed T cells.
"
5.
HIV Infections (HIV Infection)
09/01/1992 - "
Dysregulation of adult T-cell leukemia-derived factor (ADF)/thioredoxin in HIV infection: loss of ADF high-producer cells in lymphoid tissues of AIDS patients.
"
Related Drugs and Biologics
1.
Thioredoxins
2.
Cystine (L-Cystine)
3.
Interleukin-2 Receptor alpha Subunit
4.
Interleukin-2 Receptors (IL 2 Receptor)
5.
Sulfhydryl Compounds (Thiols)
6.
Cysteine (L-Cysteine)
7.
Intercellular Signaling Peptides and Proteins (Growth Factors)
8.
Complementary DNA (cDNA)
9.
Reactive Oxygen Species (Oxygen Radicals)
10.
Cytokines
Related Therapies and Procedures
1.
Lung Transplantation
2.
Transplantation