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KW 5805
structure given in first source; RN given refers to (+)-isomer
Also Known As:
5-((2-(diethylamino)ethyl)amino)-5,11-dihydro(1)-benzoxepino(3,4-b)pyridine; KW 5805, (+-)-isomer; KW 5805, (-)-isomer; KW-5805
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzoxepins: 1
KW 5805: 1
Related Diseases
1.
Ulcer
08/01/1994 - "
Effects of KW-5805, a new antiulcer agent, on various experimental ulcers, necrotizing agent-induced gastric lesions and gastric acid secretion in rats were compared with those of pirenzepine and cimetidine.
"
2.
Gastric Fistula
08/01/1994 - "
In rats with acute gastric fistula, intravenous injection of KW-5805 reduced methacholine-stimulated gastric acid secretion at doses of 10 and 30 mg/kg and inhibited tetragastrin-induced acid secretion at 30 mg/kg. These results indicate that KW-5805 has potent and broad antiulcer properties, which are probably exerted by its potent cytoprotective effect in addition to its antisecretory effect.
"
3.
Duodenal Ulcer (Curling's Ulcer)
08/01/1994 - "
KW-5805 showed antiulcer activities against experimental gastric and duodenal ulcers (ED50 = 1.2-10.0 mg/kg, p.o.).
"
08/01/1994 - "
Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion.
"
Related Drugs and Biologics
1.
Methacholine Chloride (Methacholine)
2.
Tetragastrin
3.
Pirenzepine
4.
Cimetidine (Biomet)
5.
Acids
Related Therapies and Procedures
1.
Intravenous Injections