illudin M

RN given refers to (3'S-trans)-isomer; structure in first source

Also Known As:

(3'S-trans)-2',3'-Dihydro-3'b,6'a-dihydroxy-2',2',4',6'-tetramethylspiro(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one; Spiro(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3'S,6'R)-

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Biersack, Bernhard: 3 articles (09/2011 - 09/2008)
2.	Schobert, Rainer: 3 articles (09/2011 - 09/2008)
3.	Knauer, Sebastian: 2 articles (09/2009 - 09/2008)
4.	Chaverra-Muñoz, Lillibeth: 1 article (07/2022)
5.	Hüttel, Stephan: 1 article (07/2022)
6.	Ahmad, Aamir: 1 article (09/2011)
7.	Effenberger-Neidnicht, Katharina: 1 article (09/2011)
8.	Mahal, Katharina: 1 article (09/2011)
9.	Mueller, Thomas: 1 article (09/2011)
10.	Padhye, Subhash: 1 article (09/2011)

Related Diseases

1.	Neoplasms (Cancer) 07/18/2022 - "Recently, illudin M derivatives have shown improved in vitro selectivity towards cancer cells encouraging further investigation. " 08/13/2022 - "While the fungal metabolite illudin M (1) is indiscriminately cytotoxic in cancer and non-malignant cells, its retinoate 2 showed a greater selectivity for the former, especially in a cerebral context. " 09/22/2011 - "The diester 2a obtained from 1,1'-ferrocenedicarboxylic acid and the highly and indiscriminately cytotoxic fungal metabolite illudin M (1) displayed antiproliferative activity at submicromolar IC(50) (72 h) values against a panel of eight cancer cell lines. " 09/22/2011 - "Cancer selective metallocenedicarboxylates of the fungal cytotoxin illudin M." 09/01/2009 - "The monoester of illudin M with ferrocenoic acid was nine times less efficacious in the cancer cells, when compared with the diester. "
2.	Leukemia 09/22/2011 - "A new illudin M lactone 5 was of low anticancer activity, but its ruthenocene diester 6b also reached single-digit micromolar IC(50) (72 h) values in HCT-116, MCF-7, and HL-60 leukemia cells while not affecting HF. " 09/01/2009 - "Esters of illudin M with ferrocenoic and 1,1'-ferrocenedioic acid were prepared, structurally characterised (X-ray), and tested for cytotoxicity [MTT assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], induction of apoptosis (TUNEL assay; western blotting for caspase-9), and tumor specificity in cells of human HL-60 leukemia, human 518A2 melanoma, and in nonmalignant human foreskin fibroblasts. "
3.	Melanoma (Melanoma, Malignant) 09/01/2009 - "The diester of illudin M with 1,1'-ferrocenedioic acid was distinctly more antiproliferative and apoptosis inducing in the melanoma cells [half maximal inhibitory concentration, IC50(48 h) = 0.4+/-0.1 micromol/l] than in the HL-60 cells [IC50(48 h) = 3.0+/-1.6 micromol/l] and in the nonmalignant fibroblasts [IC50(48 h) = 3.7+/-1.9 micromol/l]. " 09/01/2009 - "Melanoma-specific ferrocene esters of the fungal cytotoxin illudin M." 09/01/2009 - "Esters of illudin M with ferrocenoic and 1,1'-ferrocenedioic acid were prepared, structurally characterised (X-ray), and tested for cytotoxicity [MTT assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide], induction of apoptosis (TUNEL assay; western blotting for caspase-9), and tumor specificity in cells of human HL-60 leukemia, human 518A2 melanoma, and in nonmalignant human foreskin fibroblasts. "
4.	Glioma (Gliomas) 08/13/2022 - "Illudin M killed malignant glioma cells as well as primary neurons and astrocytes at similarly low concentrations and destroyed their microtubule and glial fibrillary acidic protein (GFAP) networks. "
5.	Chromosome Aberrations (Chromosome Abnormalities) 12/01/1989 - "The chromosomal aberration test using a Chinese hamster lung cell line (CHL) was carried out on ptaquiloside and its related compounds, hypoloside B, hypoloside C, illudin M and illudin S. "

Related Drugs and Biologics

1.	Cytotoxins (Cytolysins)
2.	Acids
3.	Esters
4.	Caspase 9
5.	Lactones
6.	Glial Fibrillary Acidic Protein
7.	Docosahexaenoic Acids
8.	Chlorambucil (Leukeran)
9.	endothall
10.	hypoloside B