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vintriptol
Also Known As:
N-(L-tryptophan ethyl ester)-4-deacetylvinblastine-3-carboxamide; VTrpE; vintripol; vintrypol
Networked:
5
relevant articles (
0
outcomes,
3
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Vinca Alkaloids: 463
Vinblastine: 3373
vintriptol: 5
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Vinca Alkaloids: 463
Vinblastine: 3373
vintriptol: 5
Indolizines: 3
Indolizidines: 2
Indole Alkaloids: 200
Secologanin Tryptamine Alkaloids: 81
Vinca Alkaloids: 463
Vinblastine: 3373
vintriptol: 5
Related Diseases
1.
Neoplasms (Cancer)
01/01/1991 - "
In this phase I study, 47 patients with advanced cancer were exposed to escalating doses of vintriptol, starting at 6 mg/m2 and following a modified Fibonacci schedule.
"
08/03/1990 - "
The applicability of the assay was demonstrated in a pharmacokinetic study with eight cancer patients who received 45 or 50 mg/m2 vintriptol in a phase I study.
"
02/14/1992 - "
The assay was applied to the analysis of samples from cancer patients who had been treated with VtrpE in a phase I clinical study.
"
2.
Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/01/1986 - "
For VTrpE, a dose schedule of 30 mg/m2 per week may be recommended for phase II studies in non-small cell lung cancer.
"
3.
Ovarian Neoplasms (Ovarian Cancer)
12/01/1992 - "
A comparative analysis was carried out of the anti-tumour activity of the four compounds as well as vintriptol in four human ovarian cancer xenografts different in histology, growth rate and chemosensitivity.
"