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5'-amino-5'-deoxythymidine
RN given refers to parent cpd
Also Known As:
5'-amino-2',5'-dideoxythymidine; 5'-amino-5'-deoxythymidine monoacetate; 5'-amino-5'-deoxythymidine monohydrochloride; 5-ADDOT
Networked:
6
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Deoxyribonucleosides: 34
Dideoxynucleosides: 27
5'-amino-5'-deoxythymidine: 6
Related Diseases
1.
Colonic Neoplasms (Colon Cancer)
06/01/1996 - "
This in vivo study examines the ability of 5'-amino-5'-deoxythymidine (5'-AdThd) to modulate 5-iododeoxyuridine (IdUrd) cellular metabolism in two human colon cancer xenografts (HT 29 and HCT-116), two actively proliferating normal mouse tissues (bone marrow and intestine), and a quiescent normal mouse tissue (liver).
"
06/01/1996 - "
In vivo modulation of iododeoxyuridine metabolism and incorporation into cellular DNA by 5'-amino-5'-deoxythymidine in normal mouse tissues and two human colon cancer xenografts.
"
2.
Urinary Bladder Neoplasms (Bladder Cancer)
11/01/1992 - "
Low pH does not affect the dose response for 5'-amino-5'-deoxythymidine modulation of IdUrd DNA incorporation and radiosensitization in a human bladder cancer cell line.
"
08/01/1993 - "
Effects of bleomycin with iododeoxyuridine, 5'-amino-5'-deoxythymidine, and radiation in a human bladder cancer cell line.
"
10/15/1989 - "
We have studied the effect of pH on the interactions between thymidine kinase, thymidine triphosphate, and 5'-amino-2',5'-dideoxythymidine (5'-AdThd) in purified preparations of the enzyme and in intact 647V cells, a human bladder cancer cell line.
"
3.
Infections
02/01/1988 - "
Treatment of herpes simplex virus type 1 (HSV-1) infected Vero cells with 5'-amino-5'-deoxythymidine (AdThd) causes a 65% reduction in the amount of total viral RNA present at late times of infection.
"
12/01/1979 - "
Synergistic effect of 5'-amino-5'-deoxythymidine and 5-iodo-2'-deoxyuridine against Herpes Simplex virus infections in vitro.
"
Related Drugs and Biologics
1.
Idoxuridine (Stoxil)
2.
DNA (Deoxyribonucleic Acid)
3.
Thymidine Kinase
4.
Viral RNA
5.
Enzymes
6.
Bleomycin (Blenoxane)
7.
thymidine 5'-triphosphate (thymidine triphosphate)