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2- amino- 6- methyldipyrido(1,2- a- 3',2'- d)imidazole
structure
Also Known As:
Glu P-1; Glu-P-1; 6-methyldipyrido(1,2-a:3',2'-d)imidazol-2-amine
Networked:
17
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole: 17
Experts
1.
Hashimoto, Yuichi
: 1 article (01/2021)
Related Diseases
1.
Neoplasms (Cancer)
06/01/1996 - "
Further, the transgene plays no significant role in the development of liver tumors induced by Glu-P-1, but does play a role in the malignant conversion of some liver tumors, as a result of its mutation.
"
06/01/1996 - "
The Ha-ras mutation in tumors developed by the groups administered Glu-P-1, was examined.
"
06/01/1996 - "
In contrast, Glu-P-1 administration induced liver tumors, both in Tg and in N-Tg; 16/17 in Tg and 13/18 in N-Tg.
"
01/01/1994 - "
The limited (20-30 times less) base substitution mutagenic potency of Glu-P-1 relative to its frameshift mutagenic potency as well as the extreme site specificity exhibited by Glu-P-1 for base substitutions may have bearing on the lack of base substitutions identified in ras genes in Glu-P-1-induced rat colon tumors.
"
08/01/1986 - "
Glu-P-1 induced intestinal tumors in a high incidence when fed orally to rats.
"
2.
Sarcoma (Soft Tissue Sarcoma)
06/01/1996 - "
Rare activation of the human c-Ha-ras transgene of mice in hemangioendothelial sarcomas and liver tumors induced by Glu-P-1.
"
01/01/1989 - "
Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1.
"
08/01/1986 - "
Hemangioendothelial sarcomas were also induced by Glu-P-1, Glu-P-2, MeA alpha C, and A alpha C.
"
3.
Chromosome Aberrations (Chromosome Abnormalities)
09/01/1992 - "
Trp-P-1, Trp-P-2, A alpha C, MeA alpha C and Glu-P-1 were weak clastogens by themselves, but at much higher concentrations than those at which they increased the induction of chromosome aberrations in cells pretreated with UV or MMC.
"
09/01/1992 - "
A alpha C, MeA alpha C, Glu-P-1, Glu-P-2, IQ, MeIQ, harman and harmine increased chromosome aberrations only in the presence of S9 mix.
"
11/01/1991 - "
Intraperitoneal injections of Trp-P-1, Glu-P-1, MeIQx, IQ and nitro-IQ resulted in chromosome aberrations in up to 16% of the metaphase cells and SCEs at up to 0.9 per chromosome, while injections of Trp-P-2 and Glu-P-2 produced SCEs at up to 0.7 and 1.1 per chromosome, respectively.
"
4.
Carcinoma (Carcinomatosis)
02/01/1998 - "
The combined incidence of hepatocellular adenomas and carcinomas in the group fed Glu-P-1 alone was 89%, in contrast to 40% with simultaneous HTHQ treatment, and near the control level of 30% without Glu-P-1 and HTHQ.
"
05/01/1994 - "
Seven carcinomas induced by Glu-P-1, and nine carcinomas and two adenomas induced by IQ were examined by cDNA-polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis from codon 103 to 391 of p53, which encompasses the conserved regions II to IV. Nine carcinomas induced by PhIP were examined by genomic PCR-SSCP analysis of exons 5 to 7 (from codon 124 to 304), which encompasses the 3' half of the conserved region II and all the conserved regions III-V. No band shifts were found in any of these tumors under at least two conditions of SSCP analysis.
"
5.
Adenoma (Adenomas)
03/15/1992 - "
Glu-P-1, IQ, PhIP, MeIQx, and 4-ABP each induced a significant incidence of hepatic adenomas, as compared to the solvent-treated (DMSO) control.
"
05/01/1994 - "
Seven carcinomas induced by Glu-P-1, and nine carcinomas and two adenomas induced by IQ were examined by cDNA-polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis from codon 103 to 391 of p53, which encompasses the conserved regions II to IV. Nine carcinomas induced by PhIP were examined by genomic PCR-SSCP analysis of exons 5 to 7 (from codon 124 to 304), which encompasses the 3' half of the conserved region II and all the conserved regions III-V. No band shifts were found in any of these tumors under at least two conditions of SSCP analysis.
"
Related Drugs and Biologics
1.
Glu-P-2
2.
Amines
3.
3- amino- 1,4- dimethyl- 5H- pyrido(4,3- b)indole
4.
2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridine
5.
3-amino-1-methyl-5H-pyrido(4,3-b)indole
6.
DNA Adducts
7.
Complementary DNA (cDNA)
8.
Solvents
9.
Mutagens
10.
Harmine (Telepathine)
Related Therapies and Procedures
1.
Intraperitoneal Injections
2.
Injections