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gamma-glutamyl DOPA
Also Known As:
gamma-glutamyl L-dopa; gamma-glutamyl-3,4-dihydroxyphenylalanine; gludopa
Networked:
12
relevant articles (
1
outcomes,
5
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Catecholamines: 15682
Dihydroxyphenylalanine: 1494
gamma-glutamyl DOPA: 12
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Catechols: 121
Catecholamines: 15682
Dihydroxyphenylalanine: 1494
gamma-glutamyl DOPA: 12
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Cyclic Amino Acids: 3
Aromatic Amino Acids: 467
Tyrosine: 10509
Dihydroxyphenylalanine: 1494
gamma-glutamyl DOPA: 12
Phenylalanine: 4090
Dihydroxyphenylalanine: 1494
gamma-glutamyl DOPA: 12
Related Diseases
1.
Renal Insufficiency (Renal Failure)
08/01/1983 - "
The administration of gamma-glutamyl L-dopa reduces the severity of renal failure produced by glycerol.
"
01/01/1989 - "
Following an outline of the medicinal chemistry bases of the development of these prodrugs, laboratory and clinical pharmacology of ibopamine, levodopa, gludopa, and TA-870 are reviewed, pointing out the interesting indications of various preliminary studies in heart failure, essential hypertension, and renal failure on the one hand, and the extensive therapeutic experience with ibopamine as an "inodilator" in the chronic treatment of congestive heart failure on the other hand.
"
2.
Essential Hypertension
01/01/1987 - "
Dopamine, the kidney and essential hypertension studies with gludopa.
"
12/01/1985 - "
The relatively kidney-specific dopamine pro-drug, gamma-L-glutamyl-L-dopa (gludopa) was administered to eight normal subjects and eight patients with essential hypertension, control studies being provided by the infusion of saline on a separate occasion.
"
01/01/1989 - "
Following an outline of the medicinal chemistry bases of the development of these prodrugs, laboratory and clinical pharmacology of ibopamine, levodopa, gludopa, and TA-870 are reviewed, pointing out the interesting indications of various preliminary studies in heart failure, essential hypertension, and renal failure on the one hand, and the extensive therapeutic experience with ibopamine as an "inodilator" in the chronic treatment of congestive heart failure on the other hand.
"
3.
Acute Kidney Injury (Acute Renal Failure)
10/01/1990 - "
The extent of metabolism in normal rats, and the pharmacokinetics in anephric rats and rats with glycerol-induced acute renal failure (ARF) were also studied at a gludopa dose of 2 mg kg-1.
"
10/01/1990 - "
The pharmacokinetics of gamma-glutamyl-L-dopa in normal and anephric rats and rats with glycerol-induced acute renal failure.
"
08/01/1983 - "
The protective effect of gamma-glutamyl L-dopa on the glycerol treated rat model of acute renal failure.
"
04/01/1994 - "
1. In this study the renal selectivity of dopamine and its prodrugs L-dopa and gludopa, with respect to their effects on regional blood flow, vascular resistance and central haemodynamics was investigated in normal rats and in rats with glycerol-induced acute renal failure (ARF).
"
04/01/1994 - "
Regional haemodynamic effects of dopamine and its prodrugs L-dopa and gludopa in the rat and in the glycerol-treated rat as a model for acute renal failure.
"
4.
Heart Failure
06/01/1993 - "
We compared the acute renal effects of gludopa in conscious control rabbits (n = 6) and rabbits with doxorubicin-induced congestive heart failure (CHF, n = 5).
"
01/01/1989 - "
Following an outline of the medicinal chemistry bases of the development of these prodrugs, laboratory and clinical pharmacology of ibopamine, levodopa, gludopa, and TA-870 are reviewed, pointing out the interesting indications of various preliminary studies in heart failure, essential hypertension, and renal failure on the one hand, and the extensive therapeutic experience with ibopamine as an "inodilator" in the chronic treatment of congestive heart failure on the other hand.
"
5.
Familial Hypophosphatemia (Phosphate Diabetes)
05/01/1999 - "
This study tested the hypothesis that, because of the unique colocalization of gamma-glutamyltransferase (gamma-GT), aromatic amino acid decarboxylase, Na(+)-Pi cotransporter, and Na(+)-L-DOPA cotransporter in brush border membrane (BBM) of proximal tubular cells, gludopa may elicit phosphaturia by action of DA generated within the kidney.
"
Related Drugs and Biologics
1.
Glycerol (Glycerine)
2.
Levodopa (L Dopa)
3.
Prodrugs
4.
Dopamine (Intropin)
5.
gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)
6.
Aromatic-L-Amino-Acid Decarboxylases
7.
ibopamine
8.
Fenoldopam (Corlopam)
9.
Dietary Sodium Chloride (Table Salt)
10.
Renin
Related Therapies and Procedures
1.
Therapeutics