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2-aminomethyl-4-t-butyl-6-iodophenol
has gastric antisecretory activity; RN given refers to parent cpd; structure
Also Known As:
2-aminomethyl-4-butyl-6-iodophenyl; 2-aminomethyl-4-t-butyl-6-iodophenol hydrochloride; MK 447; MK-447; 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenol
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Cresols: 9
Butylated Hydroxytoluene: 812
2-aminomethyl-4-t-butyl-6-iodophenol: 6
Related Diseases
1.
Inflammation (Inflammations)
08/01/1979 - "
Therefore, MK-447 cannot be used unequivocably as a tool to investigate the role of endogenous stable PGs during granulomatous inflammation.
"
08/01/1979 - "
Effects of 2-aminomethyl-4-t-butyl-6-iodophenol (MK-447) on granulomatous inflammation: lack of correlation with changes in levels of prostaglandin-like material.
"
12/01/1978 - "
The role of primary prostaglandins in ocular inflammation as demonstrated by the effects of MK-447 in the rabbit eye.
"
07/01/1983 - "
Thus, the anti-inflammatory action of MK-447 can be explained by inhibition of PGE2 generation, giving no consideration to the role of oxygen-derived free radicals as a prime mediator in inflammation.
"
12/01/1977 - "
That both MK-447 and prostaglandin synthetase inhibitors depress the enzymatic formation of PGG2 from arachidonic acid suggests that this endoperoxide plays a pivotal role in acute inflammation.
"
2.
Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1981 - "
It appears that MK-447 protects in traumatic shock and in myocardial ischemia by a mechanism related to removal of free radicals formed in arachidonic acid metabolism.
"
3.
Tachycardia (Tachyarrhythmias)
02/01/1987 - "
Antihypertensive responses to furosemide, MK-447 and the diuretic combinations were associated with either stable heart rate or paradoxical bradycardia, but not compensatory tachycardia.
"
4.
Traumatic Shock
01/01/1981 - "
It appears that MK-447 protects in traumatic shock and in myocardial ischemia by a mechanism related to removal of free radicals formed in arachidonic acid metabolism.
"
01/01/1981 - "
MK-447, a free radical scavenger, at 1-4 mg/kg, was found to prolong survival in traumatic shock and to prevent the plasma appearance of a myocardial depressant factor (MDF) in shock rats.
"
5.
Shock
01/01/1981 - "
MK-447, a free radical scavenger, at 1-4 mg/kg, was found to prolong survival in traumatic shock and to prevent the plasma appearance of a myocardial depressant factor (MDF) in shock rats.
"
Related Drugs and Biologics
1.
Arachidonic Acid (Vitamin F)
2.
Prostaglandins
3.
Free Radicals
4.
Carrageenan
5.
MB Form Creatine Kinase
6.
Cyclooxygenase Inhibitors
7.
Free Radical Scavengers
8.
Dinoprostone (PGE2)
9.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
10.
Oxygen (Dioxygen)