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beta-2'-deoxythioguanosine
RN given refers to parent cpd
Also Known As:
2'-deoxy-6-thioguanosine; beta-2'-deoxythioguanosine mono-hydrate; beta-thioguanine deoxyriboside
Networked:
12
relevant articles (
0
outcomes,
4
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
Guanosine: 1156
Deoxyguanosine: 166
beta-2'-deoxythioguanosine: 12
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
Guanosine: 1156
Deoxyguanosine: 166
beta-2'-deoxythioguanosine: 12
Deoxyribonucleosides: 34
Deoxyguanosine: 166
beta-2'-deoxythioguanosine: 12
Thionucleosides: 2
beta-2'-deoxythioguanosine: 12
Organic Chemicals: 133
Sulfur Compounds: 278
Thionucleosides: 2
beta-2'-deoxythioguanosine: 12
Related Diseases
1.
Leukemia
10/01/1977 - "
Phase II Study of beta-2'-deoxythioguanosine in adult acute leukemia.
"
06/01/1985 - "
Phase I evaluation of beta-2'-deoxythioguanosine in pediatric patients with leukemia.
"
02/01/1979 - "
Treatment of refractory adult acute leukemia with 5-azacytidine plus beta-2'-deoxythioguanosine.
"
08/01/1977 - "
Combination therapy with 5-azacytidine plus beta-2'-deoxythioguanosine in adult acute leukemia.
"
06/01/1985 - "
Thirty-one pediatric patients with acute leukemia who had relapsed on either 6-mercaptopurine or 6-thioguanine were treated with beta-2'-deoxythioguanosine, which was administered as an iv infusion every 12 hours for three or six doses every 2 weeks.
"
2.
Neoplasms (Cancer)
01/01/1982 - "
However, a new agent, beta-2'-deoxythioguanosine (beta-TGdR) can overcome TG resistance in animal tumor models and is therefore of potential clinical use.
"
05/01/1975 - "
Lack of activity of beta-2'-deoxythioguanosine against two tumors resistant to 6-thioguanine.
"
06/01/1985 - "
Phase II trials of hexamethylmelamine, dianhydrogalactitol, razoxane, and beta-2'-deoxythioguanosine as single agents against advanced measurable tumors of the pancreas.
"
06/01/1985 - "
Phase II trials of several single agents demonstrated only minimal objective response rates in patients with pancreatic carcinoma and measurable tumors: hexamethylmelamine (7%; four responses among 55 patients); dianhydrogalactitol (2.5%; one response among 40 patients); razoxane (7%; two responses among 29 patients); and beta-2'-deoxythioguanosine (6%; two responses among 32 patients).
"
01/01/1976 - "
Beta-thioguanine deoxyriboside (betaTGdR) is a purine nucleoside derivative which was studied alone or in combination with arabinosyl cytosine (Ara-C) in patients with solid tumors and acute leukemia.
"
3.
Colorectal Neoplasms (Colorectal Cancer)
08/01/1979 - "
Phase II evaluation of diglycoaldehyde, VP-16-213, and the combination of methyl-CCNU and beta-2'-deoxythioguanosine in previously treated patients with colorectal cancer: an Eastern Cooperative Oncology Group study (EST-1275).
"
08/01/1979 - "
The Eastern Cooperative Oncology Group assessed the activity of diglycoaldehyde (DGA), VP-16-213, and the combination of methyl-CCNU and beta-2'-deoxythioguanosine in previously treated patients with advanced colorectal cancer.
"
01/01/1981 - "
Two hundred twenty eligible patients with metastatic colorectal carcinoma were treated with a combination of beta-2'-deoxythioguanosine (BTG), plus methyl-CCNU or mitomycin.
"
01/01/1981 - "
Evaluation of beta-2'-deoxythioguanosine combined with methyl-CCNU or mitomycin in advanced colorectal cancer.
"
4.
Pancreatic Neoplasms (Pancreatic Cancer)
06/01/1985 - "
Phase II trials of several single agents demonstrated only minimal objective response rates in patients with pancreatic carcinoma and measurable tumors: hexamethylmelamine (7%; four responses among 55 patients); dianhydrogalactitol (2.5%; one response among 40 patients); razoxane (7%; two responses among 29 patients); and beta-2'-deoxythioguanosine (6%; two responses among 32 patients).
"
5.
Carcinoma (Carcinomatosis)
12/01/1978 - "
Chemotherapy of advanced measurable colon and rectal carcinoma with oral 5-fluorouracil, alone or in combination with cyclophosphamide or 6-thioguanine, with intravenous 5-fluorouracil or beta-2'-deoxythioguanosine or with oral 3(4-methyl-cyclohexyl)-1(2-chlorethyl)-1-nitrosourea: a Phase II-III study of the Eastern Cooperative Oncology Group (EST 4273).
"
Related Drugs and Biologics
1.
Thioguanine (Tioguanine)
2.
Semustine
3.
Razoxane
4.
Altretamine (Hemel)
5.
Fluorouracil (Carac)
6.
Dianhydrogalactitol
7.
Cyclophosphamide (Cytoxan)
8.
Cytarabine (Cytosar-U)
9.
Azacitidine (5 Azacytidine)
10.
Mitomycin (Mitomycin-C)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)
2.
Therapeutics