fotrin

ethyleneamine derivative; antineoplastic; Russian drug; structure

Also Known As:

2,2,4,4,6-pentaethyleneimino-6-morpholinocyclotriphosphazatriene; 2,2,4,4,6-pentakis(1-aziridinyl)-2,2,4,4,6,6-hexahydro-6-(4-morpholinyl)-1,3, 5,2,4,6-triazatriphosphorine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azirines
    - Aziridines: 14
      - fotrin: 5

Related Diseases

1.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/1993 - "Using the method of counting micronuclei it was shown that, in peripheral blood of larva of frog exposed to high doses of alkylating agent fotrin, the abundance of erythrocytes with signs of chromosomal aberrations significantly exceeds the level of spontaneous mutations on the 16th, 24th and 30th days of fixation but not on the 7th day following the experiment onset. " 10/01/1988 - "Activity of mixed function of oxygenases (content of cytochromes P-450) were enhanced after PB treatment in doses 2 and 10 mg/kg. Following PB treatment the animals were injected 5-times ethyleneimine derivate--fotrin at the doses 2, 4 and 7 mg/kg. The induction of mixed function of oxygenases resulted in significant decrease in the number of cells with chromosome aberrations."
2.	Lewis Lung Carcinoma 01/01/1993 - "[The genetic correction of the mutagenic properties of fotrin by using the interferon inducer larifan in spontaneously metastasizing Lewis lung carcinoma]."
3.	Wounds and Injuries (Trauma) 12/01/1988 - "The paper deals with the modifying effects of natural (leukocytic) and synthesized (recombinant) interferons on the number of cytogenetic injuries in the cultured lymphocytes of human peripheric blood after exposure to alkylating chemicals--thio-TEPA and fotrin. "
4.	Polycythemia Vera 08/01/1980 - "[Use of the Soviet preparations, fotrin and imifos, in erythremia]."

Related Drugs and Biologics

1.	Interferons
2.	Thiotepa (Triethylenethiophosphoramide)
3.	Oxygenases
4.	Cytochromes
5.	Alkylating Agents
6.	larifan
7.	aziridine (ethyleneimine)
8.	imiphos